Longitudinal pharmacogenomic analysis of refractory lung cancer to identify therapeutic candidates for epidermal growth factor receptor–tyrosine kinase inhibitor resistance subclones

Longitudinal pharmacogenomic analysis of refractory lung cancer to identify therapeutic candidates for epidermal growth factor receptor–tyrosine kinase inhibitor resistance subclones

Abstract The dynamic nature of longitudinal tumor evolution across patients presents challenges in designing effective drugs. Here we aimed to determine tumor evolution resistance mechanisms and explore candidate drugs for specific tumor evolution types. We conducted longitudinal pharmacogenomic ana...

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Bibliographic Details
Main Authors: Namhee Yu, Mihwa Hwang, Beung Chul Ahn, Youngjoo Lee, Sehwa Hong, Hanna Sim, Bo Ram Song, Sunshin Kim, Charny Park, Ji-Youn Han
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01493-2
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