The health impacts and genetic architecture of food liking in cardio-metabolic diseases
Abstract We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565–977,323) for genetic analyses. Integ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59945-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128191470960640 |
|---|---|
| author | Wenbo Jiang Hang Wang Yiding Geng Meijuan Guo Yingdong Zuo Sijia Han Zijie Liu Shuaijun Chen Shuzhen Fan Shangying Li Conghui Qiao Qianzhu Li Bai Li Yunpeng Zhang Wei Wei Tianshu Han |
| author_facet | Wenbo Jiang Hang Wang Yiding Geng Meijuan Guo Yingdong Zuo Sijia Han Zijie Liu Shuaijun Chen Shuzhen Fan Shangying Li Conghui Qiao Qianzhu Li Bai Li Yunpeng Zhang Wei Wei Tianshu Han |
| author_sort | Wenbo Jiang |
| collection | DOAJ |
| description | Abstract We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565–977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases. |
| format | Article |
| id | doaj-art-11371c1b9cfe44cfb283dcf6e22cdb73 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-11371c1b9cfe44cfb283dcf6e22cdb732025-08-20T02:33:25ZengNature PortfolioNature Communications2041-17232025-05-0116112010.1038/s41467-025-59945-2The health impacts and genetic architecture of food liking in cardio-metabolic diseasesWenbo Jiang0Hang Wang1Yiding Geng2Meijuan Guo3Yingdong Zuo4Sijia Han5Zijie Liu6Shuaijun Chen7Shuzhen Fan8Shangying Li9Conghui Qiao10Qianzhu Li11Bai Li12Yunpeng Zhang13Wei Wei14Tianshu Han15Key Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityDepartment of Biology, University of OttawaCollege of Bioinformatics Science and Technology, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityKey Laboratory of Precision Nutrition and Health, Ministry of Education. Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical UniversityAbstract We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565–977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases.https://doi.org/10.1038/s41467-025-59945-2 |
| spellingShingle | Wenbo Jiang Hang Wang Yiding Geng Meijuan Guo Yingdong Zuo Sijia Han Zijie Liu Shuaijun Chen Shuzhen Fan Shangying Li Conghui Qiao Qianzhu Li Bai Li Yunpeng Zhang Wei Wei Tianshu Han The health impacts and genetic architecture of food liking in cardio-metabolic diseases Nature Communications |
| title | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| title_full | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| title_fullStr | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| title_full_unstemmed | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| title_short | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| title_sort | health impacts and genetic architecture of food liking in cardio metabolic diseases |
| url | https://doi.org/10.1038/s41467-025-59945-2 |
| work_keys_str_mv | AT wenbojiang thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT hangwang thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yidinggeng thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT meijuanguo thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yingdongzuo thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT sijiahan thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT zijieliu thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shuaijunchen thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shuzhenfan thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shangyingli thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT conghuiqiao thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT qianzhuli thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT baili thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yunpengzhang thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT weiwei thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT tianshuhan thehealthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT wenbojiang healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT hangwang healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yidinggeng healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT meijuanguo healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yingdongzuo healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT sijiahan healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT zijieliu healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shuaijunchen healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shuzhenfan healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT shangyingli healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT conghuiqiao healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT qianzhuli healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT baili healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT yunpengzhang healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT weiwei healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases AT tianshuhan healthimpactsandgeneticarchitectureoffoodlikingincardiometabolicdiseases |