Sibutramine as a Cause of Sudden Cardiac Death
Importance. Sibutramine was withdrawn from the US market due to association with adverse cardiovascular outcomes especially with patients having preexisting cardiac disease. However, continued presence of sibutramine in herbal medications is a concern to public safety. Results. We report a case of a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2021/8896932 |
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| author | Miguel Rodriguez-Guerra Mayank Yadav Manoj Bhandari Archna Sinha Jonathan N. Bella Eduard Sklyar |
| author_facet | Miguel Rodriguez-Guerra Mayank Yadav Manoj Bhandari Archna Sinha Jonathan N. Bella Eduard Sklyar |
| author_sort | Miguel Rodriguez-Guerra |
| collection | DOAJ |
| description | Importance. Sibutramine was withdrawn from the US market due to association with adverse cardiovascular outcomes especially with patients having preexisting cardiac disease. However, continued presence of sibutramine in herbal medications is a concern to public safety. Results. We report a case of a patient with no evidence of previous coronary heart disease, who presented with non-ST elevation acute coronary syndrome (NSTE-ACS). Urgent coronary catheterization showed nonobstructive coronaries. However, patient died unexpectedly within 24 hours of admission. The patient denied toxic habits but was taking over-the-counter weight loss herbal supplements. Complete autopsy was performed which showed sibutramine in the toxicology. Patient died due to complications of acute inadvertent intoxication of sibutramine. Conclusion and Relevance. This is the first case report in literature showing association of sibutramine to sudden cardiac death in patients with no prior cardiac history. The continued presence of sibutramine in some over-the-counter weight loss formulations is a very concerning public health issue. |
| format | Article |
| id | doaj-art-1136304ade9f44bdbbe78b99a0e0d384 |
| institution | OA Journals |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-1136304ade9f44bdbbe78b99a0e0d3842025-08-20T02:01:53ZengWileyCase Reports in Cardiology2090-64042090-64122021-01-01202110.1155/2021/88969328896932Sibutramine as a Cause of Sudden Cardiac DeathMiguel Rodriguez-Guerra0Mayank Yadav1Manoj Bhandari2Archna Sinha3Jonathan N. Bella4Eduard Sklyar5BronxCare Health System, New York, USABronxCare Health System, New York, USABronxCare Health System, New York, USASt. Charles Hospital, Port Jefferson, New York, USABronxCare Health System, New York, USABronxCare Health System, New York, USAImportance. Sibutramine was withdrawn from the US market due to association with adverse cardiovascular outcomes especially with patients having preexisting cardiac disease. However, continued presence of sibutramine in herbal medications is a concern to public safety. Results. We report a case of a patient with no evidence of previous coronary heart disease, who presented with non-ST elevation acute coronary syndrome (NSTE-ACS). Urgent coronary catheterization showed nonobstructive coronaries. However, patient died unexpectedly within 24 hours of admission. The patient denied toxic habits but was taking over-the-counter weight loss herbal supplements. Complete autopsy was performed which showed sibutramine in the toxicology. Patient died due to complications of acute inadvertent intoxication of sibutramine. Conclusion and Relevance. This is the first case report in literature showing association of sibutramine to sudden cardiac death in patients with no prior cardiac history. The continued presence of sibutramine in some over-the-counter weight loss formulations is a very concerning public health issue.http://dx.doi.org/10.1155/2021/8896932 |
| spellingShingle | Miguel Rodriguez-Guerra Mayank Yadav Manoj Bhandari Archna Sinha Jonathan N. Bella Eduard Sklyar Sibutramine as a Cause of Sudden Cardiac Death Case Reports in Cardiology |
| title | Sibutramine as a Cause of Sudden Cardiac Death |
| title_full | Sibutramine as a Cause of Sudden Cardiac Death |
| title_fullStr | Sibutramine as a Cause of Sudden Cardiac Death |
| title_full_unstemmed | Sibutramine as a Cause of Sudden Cardiac Death |
| title_short | Sibutramine as a Cause of Sudden Cardiac Death |
| title_sort | sibutramine as a cause of sudden cardiac death |
| url | http://dx.doi.org/10.1155/2021/8896932 |
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