Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents

Abstract Background Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. While interest in its applications for adolescents is growing, critical gaps remain in understanding safe and effective delivery of P...

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Main Authors: Sarah Forsberg, Amanda E. Downey, Lindsey D. Bruett, Lisa Hail, Gisele Fernandes-Osterhold, Josh D. Woolley, Adele Lafrance, Marissa Raymond-Flesch
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Child and Adolescent Psychiatry and Mental Health
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Online Access:https://doi.org/10.1186/s13034-025-00930-4
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author Sarah Forsberg
Amanda E. Downey
Lindsey D. Bruett
Lisa Hail
Gisele Fernandes-Osterhold
Josh D. Woolley
Adele Lafrance
Marissa Raymond-Flesch
author_facet Sarah Forsberg
Amanda E. Downey
Lindsey D. Bruett
Lisa Hail
Gisele Fernandes-Osterhold
Josh D. Woolley
Adele Lafrance
Marissa Raymond-Flesch
author_sort Sarah Forsberg
collection DOAJ
description Abstract Background Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. While interest in its applications for adolescents is growing, critical gaps remain in understanding safe and effective delivery of PAT to this vulnerable population, including implications for caregiver/family (used interchangeably) involvement in the intervention. Caregivers play a crucial role in adolescent mental health treatment by supporting recovery and disrupting illness-maintaining patterns. They also benefit from resources to navigate the challenges of caregiving. This review synthesizes existing literature on evidence-based adolescent mental health treatments, best practices in PAT delivery, and family systems theory to propose a framework for integrating caregivers in adolescent PAT. Conclusion Current literature in both PAT and adolescent mental health provides a compelling case for the direct involvement of caregivers in PAT for adolescent populations. In modern PAT, therapeutic setting (i.e., “set and setting”) is increasingly recognized as essential for optimizing outcomes. Similarly, the family system serves as a critical setting that may shape PAT efficacy in adolescents. This review provides recommendations and unique considerations for the incorporation of caregivers into PAT protocols for adolescents to maximize safety and efficacy of the intervention.
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series Child and Adolescent Psychiatry and Mental Health
spelling doaj-art-1135c5f5467848eb8a7d218f259dc1d92025-08-20T03:25:16ZengBMCChild and Adolescent Psychiatry and Mental Health1753-20002025-06-011911910.1186/s13034-025-00930-4Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescentsSarah Forsberg0Amanda E. Downey1Lindsey D. Bruett2Lisa Hail3Gisele Fernandes-Osterhold4Josh D. Woolley5Adele Lafrance6Marissa Raymond-Flesch7Department of Psychiatry and Behavioral Sciences, University of California, San FranciscoDepartment of Psychiatry and Behavioral Sciences, University of California, San FranciscoDepartment of Psychiatry and Behavioral Sciences, University of California, San FranciscoDepartment of Psychiatry and Behavioral Sciences, University of California, San FranciscoDepartment of Psychiatry and Behavioral Sciences, University of California, San FranciscoDepartment of Psychiatry and Behavioral Sciences, University of California, San FranciscoEmotion Science, Department of ResearchDepartment of Pediatrics, University of California, San FranciscoAbstract Background Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. While interest in its applications for adolescents is growing, critical gaps remain in understanding safe and effective delivery of PAT to this vulnerable population, including implications for caregiver/family (used interchangeably) involvement in the intervention. Caregivers play a crucial role in adolescent mental health treatment by supporting recovery and disrupting illness-maintaining patterns. They also benefit from resources to navigate the challenges of caregiving. This review synthesizes existing literature on evidence-based adolescent mental health treatments, best practices in PAT delivery, and family systems theory to propose a framework for integrating caregivers in adolescent PAT. Conclusion Current literature in both PAT and adolescent mental health provides a compelling case for the direct involvement of caregivers in PAT for adolescent populations. In modern PAT, therapeutic setting (i.e., “set and setting”) is increasingly recognized as essential for optimizing outcomes. Similarly, the family system serves as a critical setting that may shape PAT efficacy in adolescents. This review provides recommendations and unique considerations for the incorporation of caregivers into PAT protocols for adolescents to maximize safety and efficacy of the intervention.https://doi.org/10.1186/s13034-025-00930-4AdolescencePsychedelicsFamily
spellingShingle Sarah Forsberg
Amanda E. Downey
Lindsey D. Bruett
Lisa Hail
Gisele Fernandes-Osterhold
Josh D. Woolley
Adele Lafrance
Marissa Raymond-Flesch
Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
Child and Adolescent Psychiatry and Mental Health
Adolescence
Psychedelics
Family
title Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
title_full Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
title_fullStr Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
title_full_unstemmed Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
title_short Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents
title_sort leveraging family and caregiver support in psychedelic assisted therapy considerations for the treatment of adolescents
topic Adolescence
Psychedelics
Family
url https://doi.org/10.1186/s13034-025-00930-4
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