Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool

Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool

Abstract Embryonic macrophages emerge before the onset of definitive hematopoiesis, seed into discrete tissues and contribute to specialized resident macrophages throughout life. Presence of embryonic macrophages in the bone marrow and functional impact on hematopoietic stem cells (HSC) or the niche...

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Bibliographic Details
Main Authors: Gülce Perçin, Konstantin Riege, Julia Fröbel, Jonas Metz, Stephan Culemann, Mathias Lesche, Susanne Reinhardt, Thomas Höfer, Steve Hoffmann, Claudia Waskow
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59059-9
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