Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice

Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice

The free radical theory of aging suggests that oxidative stress from free radicals contributes to aging. While free radicals cause DNA damage and cellular dysfunction, they also regulate essential signaling pathways. This duality complicates direct testing of the theory in mice, as demonstrated by t...

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Bibliographic Details
Main Authors: Anke Geng, Xiaona Wang, Zhenkai Wu, Zhihao Liu, Xiao Huang, Xiyue Wang, Xiaoxiang Sun, Yingjie Wang, Jiayu Chen, Ying Jiang, Huanyin Tang, Zhiyong Mao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Genomic stability
Progeroid
Oxidative stress
Sirt2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002836
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