ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality

Cancer immunotherapy predominantly targets CD8 T cells, but recent evidence highlights the importance of CD4 T cells in adoptive cell therapy (ACT). The TAM receptor MerTK regulates immune responses and has been shown to provide costimulatory signals in CD8 T cells. However, its role in CD4 T cells...

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Bibliographic Details
Main Authors: Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Adoptive cell therapy
immunotherapy
melanoma
T cell
TAM-receptor
tumour infiltrating lymphocyte
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2532662
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