Discretized representations in V1 predict suboptimal orientation discrimination
Abstract Neuronal population activity in sensory cortices is the substrate for perceptual decisions. Yet, we still do not understand how neuronal information content in sensory cortices relates to behavioral reports. To reconcile neurometric and psychometric performance, we recorded the activity of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55409-1 |
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| _version_ | 1841559191502716928 |
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| author | Julien Corbo O. Batuhan Erkat John McClure Hussein Khdour Pierre-Olivier Polack |
| author_facet | Julien Corbo O. Batuhan Erkat John McClure Hussein Khdour Pierre-Olivier Polack |
| author_sort | Julien Corbo |
| collection | DOAJ |
| description | Abstract Neuronal population activity in sensory cortices is the substrate for perceptual decisions. Yet, we still do not understand how neuronal information content in sensory cortices relates to behavioral reports. To reconcile neurometric and psychometric performance, we recorded the activity of V1 neurons in mice performing a Go/NoGo orientation discrimination task. We found that, around the discrimination threshold, V1 does not represent the orientation of the stimuli as canonically expected. Instead, it forms categorical representations characterized by a relocation of activity at task-relevant domains of the orientation representational space. The relative neuronal activity at those discrete domains accurately predicted the probabilities of the animals’ decisions. Our results thus suggest that the categorical integration of discretized feature representations from sensory cortices explains perceptual decisions. |
| format | Article |
| id | doaj-art-1131b2765e964814aa1b0ca8adcd42c7 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-1131b2765e964814aa1b0ca8adcd42c72025-01-05T12:40:11ZengNature PortfolioNature Communications2041-17232025-01-0116111610.1038/s41467-024-55409-1Discretized representations in V1 predict suboptimal orientation discriminationJulien Corbo0O. Batuhan Erkat1John McClure2Hussein Khdour3Pierre-Olivier Polack4Center for Molecular and Behavioral Neuroscience, Rutgers University—NewarkCenter for Molecular and Behavioral Neuroscience, Rutgers University—NewarkCenter for Molecular and Behavioral Neuroscience, Rutgers University—NewarkCenter for Molecular and Behavioral Neuroscience, Rutgers University—NewarkCenter for Molecular and Behavioral Neuroscience, Rutgers University—NewarkAbstract Neuronal population activity in sensory cortices is the substrate for perceptual decisions. Yet, we still do not understand how neuronal information content in sensory cortices relates to behavioral reports. To reconcile neurometric and psychometric performance, we recorded the activity of V1 neurons in mice performing a Go/NoGo orientation discrimination task. We found that, around the discrimination threshold, V1 does not represent the orientation of the stimuli as canonically expected. Instead, it forms categorical representations characterized by a relocation of activity at task-relevant domains of the orientation representational space. The relative neuronal activity at those discrete domains accurately predicted the probabilities of the animals’ decisions. Our results thus suggest that the categorical integration of discretized feature representations from sensory cortices explains perceptual decisions.https://doi.org/10.1038/s41467-024-55409-1 |
| spellingShingle | Julien Corbo O. Batuhan Erkat John McClure Hussein Khdour Pierre-Olivier Polack Discretized representations in V1 predict suboptimal orientation discrimination Nature Communications |
| title | Discretized representations in V1 predict suboptimal orientation discrimination |
| title_full | Discretized representations in V1 predict suboptimal orientation discrimination |
| title_fullStr | Discretized representations in V1 predict suboptimal orientation discrimination |
| title_full_unstemmed | Discretized representations in V1 predict suboptimal orientation discrimination |
| title_short | Discretized representations in V1 predict suboptimal orientation discrimination |
| title_sort | discretized representations in v1 predict suboptimal orientation discrimination |
| url | https://doi.org/10.1038/s41467-024-55409-1 |
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