Correlation analysis of BDNF,GDNF and quality of life in young patients accepting maintenance hemodialysis
Objective To analyze the correlation of psychological status,brain derived neurotrophic factor(BDNF) and glial cell-derived neurotrophic factor(GDNF) levels in young patients accepting maintenance hemodialysis.Methods Ninety-seven cases of young patients accepting maintenance hemodialysis were selec...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57918577&Fpath=home&index=0 |
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| Summary: | Objective To analyze the correlation of psychological status,brain derived neurotrophic factor(BDNF) and glial cell-derived neurotrophic factor(GDNF) levels in young patients accepting maintenance hemodialysis.Methods Ninety-seven cases of young patients accepting maintenance hemodialysis were selected as the observation group,while 50 cases of healthy people were chosen as the control group.The symptom check list-90(SCL-90) was used to assess mental and psychological state.BDNF and GDNF were tested using ELISA.The relationship between psychological state and BDNF,GDNF was also analyzed.Results Somatization,depression,anxiety,and hostility scores in the observation group were significantly increased as compared with the norm and those in the control group(P<0.05).There was no significant difference in interpersonal relationships,terror,paranoid,and psychotic scores between the observation group with the norm and the control group(P>0.05).GDNF and BDNF in the observation group were significantly decreased as compared with the control group(P<0.05).There was no significant difference between male and female patients in the observation group(P>0.05).Correlation analysis showed that somatization and hostility in SCL-90 scores showed no significant negative correlation with BDNF(r =- 0.028,- 0.047,P>0.05),and obsessive-compressive,anxiety and depression showed significant correlation with BDNF(r=-0.317,- 0.294,- 0.309,P<0.05).Somatization and hostility in SCL-90 scores showed no significant negative correlation with GDNF(r =- 0.079,0.021,P>0.05),and obsessive-compressive,anxiety and depression showed significant correlation with GDNF(r=- 0.395,- 0.317,- 0.374,P<0.05).Conclusions Psychological status in young patients accepting maintenance hemodialysis showed decreased BDNF and GDNF as well as psychological disorders such as anxiety,depression,etc.The decreases in GDNF and BDNF may contribute to psychological disorder. |
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| ISSN: | 1671-2390 |