Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment

Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment

Background Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleukin 1 (IL-1) signaling has been implicated as a dri...

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Main Authors: David Liberg, Petter Skoog, Caitríona Grönberg, Nils Hansen, Pablo Peña-Martínez, Katrin Reinbach, Finja C Hansen, Susanne Larsson Faria, Kawther Abdilleh, Susanne Magnusson, Karin von Wachenfeldt, Camilla Rydberg Millrud, Marcus Järås
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e009523.full
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