Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/143 |
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| author | Pavel P. Tregub Yulia K. Komleva Maria V. Kukla Anton S. Averchuk Anna S. Vetchinova Natalia A. Rozanova Sergey N. Illarioshkin Alla B. Salmina |
| author_facet | Pavel P. Tregub Yulia K. Komleva Maria V. Kukla Anton S. Averchuk Anna S. Vetchinova Natalia A. Rozanova Sergey N. Illarioshkin Alla B. Salmina |
| author_sort | Pavel P. Tregub |
| collection | DOAJ |
| description | Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory. In addition, IEGs are involved in the regulation of brain cells’ metabolism, proliferation, and survival, in the establishment of multicellular ensembles, and, presumably, in cell competition in the tissue. In this review, we analyze the current understanding of the role of IEGs (c-Fos, c-Myc, Arg3.1/Arc) in controlling brain plasticity in physiological and pathological conditions, including brain aging and neurodegeneration. This work might inspire new gene therapy strategies targeting IEGs to regulate synaptic plasticity, and potentially prevent or mitigate neurodegenerative diseases. |
| format | Article |
| id | doaj-art-112d9cc8c4d043c0b3c6690f7f01900e |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-112d9cc8c4d043c0b3c6690f7f01900e2025-01-24T13:26:50ZengMDPI AGCells2073-44092025-01-0114214310.3390/cells14020143Brain Plasticity and Cell Competition: Immediate Early Genes Are the FocusPavel P. Tregub0Yulia K. Komleva1Maria V. Kukla2Anton S. Averchuk3Anna S. Vetchinova4Natalia A. Rozanova5Sergey N. Illarioshkin6Alla B. Salmina7Research Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaI.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaBrain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory. In addition, IEGs are involved in the regulation of brain cells’ metabolism, proliferation, and survival, in the establishment of multicellular ensembles, and, presumably, in cell competition in the tissue. In this review, we analyze the current understanding of the role of IEGs (c-Fos, c-Myc, Arg3.1/Arc) in controlling brain plasticity in physiological and pathological conditions, including brain aging and neurodegeneration. This work might inspire new gene therapy strategies targeting IEGs to regulate synaptic plasticity, and potentially prevent or mitigate neurodegenerative diseases.https://www.mdpi.com/2073-4409/14/2/143neuroplasticitycell competitionimmediate early genesArg3.1/Arcc-Mycc-Fos |
| spellingShingle | Pavel P. Tregub Yulia K. Komleva Maria V. Kukla Anton S. Averchuk Anna S. Vetchinova Natalia A. Rozanova Sergey N. Illarioshkin Alla B. Salmina Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus Cells neuroplasticity cell competition immediate early genes Arg3.1/Arc c-Myc c-Fos |
| title | Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus |
| title_full | Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus |
| title_fullStr | Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus |
| title_full_unstemmed | Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus |
| title_short | Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus |
| title_sort | brain plasticity and cell competition immediate early genes are the focus |
| topic | neuroplasticity cell competition immediate early genes Arg3.1/Arc c-Myc c-Fos |
| url | https://www.mdpi.com/2073-4409/14/2/143 |
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