Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis
Backgrounds Hemophagocytic lymphohistiocytosis (HLH) is an acute, rapidly progressive systemic inflammatory disorder that often occurs secondary to hematological malignancies among other conditions in adults. Although the annual incidence of HLH is increasing, detailed epidemiological knowledge of H...
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2431397 |
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| author | Qi Zhang Qiuyan Yu Qian Chen Hongjing Dong Min Fang Na Liu Wen Li Hui Wang Nan Zhao Xunxun Zhu Kui Zhang Chi Zhou |
| author_facet | Qi Zhang Qiuyan Yu Qian Chen Hongjing Dong Min Fang Na Liu Wen Li Hui Wang Nan Zhao Xunxun Zhu Kui Zhang Chi Zhou |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | Backgrounds Hemophagocytic lymphohistiocytosis (HLH) is an acute, rapidly progressive systemic inflammatory disorder that often occurs secondary to hematological malignancies among other conditions in adults. Although the annual incidence of HLH is increasing, detailed epidemiological knowledge of HLH is still limited, especially in patients with hematological malignancies.Objectives To analyze the impact of hematological malignancies on the epidemiology and outcomes of HLH.Study design Data from the National Readmission Database (NRD) from 2011 to 2020 were analyzed to explore the epidemiological trends and in-hospital outcomes of HLH patients, particularly those with hematological malignancies.Results Our analysis included 7579 HLH hospitalizations, with hematological malignancies implicated in 24.01% of cases. Our findings reveal a steady increase in HLH diagnoses from 145 cases in 2011 to 1848 in 2020, with the proportion linked to hematological malignancies remaining consistent. Patients with hematological malignancies-associated HLH exhibited higher rates of in-hospital mortality (31.6%) than those without (14.4%), and a higher 30-day readmission rate, underscoring a critical need for early detection and treatment revision.Conclusions Despite the increasing awareness and diagnosis of HLH, the prognosis of patients with HLH associated with hematological malignancies remains poor, highlighting the urgent need for improved management strategies and therapeutic interventions. |
| format | Article |
| id | doaj-art-112d6b30119845be9694aa2ad8345cf8 |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-112d6b30119845be9694aa2ad8345cf82024-12-12T15:08:53ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2431397Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosisQi Zhang0Qiuyan Yu1Qian Chen2Hongjing Dong3Min Fang4Na Liu5Wen Li6Hui Wang7Nan Zhao8Xunxun Zhu9Kui Zhang10Chi Zhou11Department of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Hematology, Tengzhou Central People’s Hospital, Tengzhou, People’s Republic of ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of ChinaBackgrounds Hemophagocytic lymphohistiocytosis (HLH) is an acute, rapidly progressive systemic inflammatory disorder that often occurs secondary to hematological malignancies among other conditions in adults. Although the annual incidence of HLH is increasing, detailed epidemiological knowledge of HLH is still limited, especially in patients with hematological malignancies.Objectives To analyze the impact of hematological malignancies on the epidemiology and outcomes of HLH.Study design Data from the National Readmission Database (NRD) from 2011 to 2020 were analyzed to explore the epidemiological trends and in-hospital outcomes of HLH patients, particularly those with hematological malignancies.Results Our analysis included 7579 HLH hospitalizations, with hematological malignancies implicated in 24.01% of cases. Our findings reveal a steady increase in HLH diagnoses from 145 cases in 2011 to 1848 in 2020, with the proportion linked to hematological malignancies remaining consistent. Patients with hematological malignancies-associated HLH exhibited higher rates of in-hospital mortality (31.6%) than those without (14.4%), and a higher 30-day readmission rate, underscoring a critical need for early detection and treatment revision.Conclusions Despite the increasing awareness and diagnosis of HLH, the prognosis of patients with HLH associated with hematological malignancies remains poor, highlighting the urgent need for improved management strategies and therapeutic interventions.https://www.tandfonline.com/doi/10.1080/16078454.2024.2431397Hemophagocytic lymphohistiocytosisNational Readmission Databasehematological malignanciestrendmortalityreadmission rate |
| spellingShingle | Qi Zhang Qiuyan Yu Qian Chen Hongjing Dong Min Fang Na Liu Wen Li Hui Wang Nan Zhao Xunxun Zhu Kui Zhang Chi Zhou Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis Hematology Hemophagocytic lymphohistiocytosis National Readmission Database hematological malignancies trend mortality readmission rate |
| title | Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| title_full | Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| title_fullStr | Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| title_full_unstemmed | Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| title_short | Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| title_sort | prevalence trends and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis |
| topic | Hemophagocytic lymphohistiocytosis National Readmission Database hematological malignancies trend mortality readmission rate |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2431397 |
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