Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension
Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed usin...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2007-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1389 |
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| author | Y. R. Timasheva T. R. Nasibullin A. N. Zakirova O. E. Mustafina |
| author_facet | Y. R. Timasheva T. R. Nasibullin A. N. Zakirova O. E. Mustafina |
| author_sort | Y. R. Timasheva |
| collection | DOAJ |
| description | Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis. Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83). Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients. |
| format | Article |
| id | doaj-art-111dda4a69c6452d8e491bef1b60d199 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2007-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-111dda4a69c6452d8e491bef1b60d1992025-08-20T03:21:39Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-12-0166591099Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertensionY. R. Timasheva0T. R. Nasibullin1A. N. Zakirova2O. E. Mustafina3Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of ScienceInstitute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of ScienceBashkir State Medical University, UfaInstitute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of ScienceAim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis. Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83). Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients.https://cardiovascular.elpub.ru/jour/article/view/1389primary (essential) arterial hypertensioncytokinesgene polymorphismstrokeassociation analysis |
| spellingShingle | Y. R. Timasheva T. R. Nasibullin A. N. Zakirova O. E. Mustafina Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension Кардиоваскулярная терапия и профилактика primary (essential) arterial hypertension cytokines gene polymorphism stroke association analysis |
| title | Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| title_full | Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| title_fullStr | Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| title_full_unstemmed | Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| title_short | Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| title_sort | tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension |
| topic | primary (essential) arterial hypertension cytokines gene polymorphism stroke association analysis |
| url | https://cardiovascular.elpub.ru/jour/article/view/1389 |
| work_keys_str_mv | AT yrtimasheva tumornecrosisfactoralphagenepolymorphisminpatientswihtessentialhypertension AT trnasibullin tumornecrosisfactoralphagenepolymorphisminpatientswihtessentialhypertension AT anzakirova tumornecrosisfactoralphagenepolymorphisminpatientswihtessentialhypertension AT oemustafina tumornecrosisfactoralphagenepolymorphisminpatientswihtessentialhypertension |