Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension
Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed usin...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2007-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1389 |
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| Summary: | Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH). Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis. Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83). Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients. |
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| ISSN: | 1728-8800 2619-0125 |