Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into mic...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2012/564348 |
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| author | Gregory J. Zilinskas Abdolrasoul Soleimani Elizabeth R. Gillies |
| author_facet | Gregory J. Zilinskas Abdolrasoul Soleimani Elizabeth R. Gillies |
| author_sort | Gregory J. Zilinskas |
| collection | DOAJ |
| description | Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems. |
| format | Article |
| id | doaj-art-111bf91534024109b3d928dc62d8d52d |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-111bf91534024109b3d928dc62d8d52d2025-08-20T03:55:45ZengWileyInternational Journal of Polymer Science1687-94221687-94302012-01-01201210.1155/2012/564348564348Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery VehiclesGregory J. Zilinskas0Abdolrasoul Soleimani1Elizabeth R. Gillies2Biomedical Engineering Graduate Program, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, CanadaMicelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.http://dx.doi.org/10.1155/2012/564348 |
| spellingShingle | Gregory J. Zilinskas Abdolrasoul Soleimani Elizabeth R. Gillies Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles International Journal of Polymer Science |
| title | Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles |
| title_full | Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles |
| title_fullStr | Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles |
| title_full_unstemmed | Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles |
| title_short | Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles |
| title_sort | poly ester amide poly ethylene oxide graft copolymers towards micellar drug delivery vehicles |
| url | http://dx.doi.org/10.1155/2012/564348 |
| work_keys_str_mv | AT gregoryjzilinskas polyesteramidepolyethyleneoxidegraftcopolymerstowardsmicellardrugdeliveryvehicles AT abdolrasoulsoleimani polyesteramidepolyethyleneoxidegraftcopolymerstowardsmicellardrugdeliveryvehicles AT elizabethrgillies polyesteramidepolyethyleneoxidegraftcopolymerstowardsmicellardrugdeliveryvehicles |