Multipool-CEST and CEST-based pH assessment as predictive tools for glioma grading, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation in gliomas

Multipool-CEST and CEST-based pH assessment as predictive tools for glioma grading, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation in gliomas

ObjectivesTo comprehensively and noninvasively predict glioma grade, IDH mutation status, 1p/19q codeletion status, and MGMT promoter methylation status using chemical exchange saturation transfer (CEST)-based tumor pH assessment and metabolic profiling.MethodsWe analyzed 128 patients with pathologi...

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Bibliographic Details
Main Authors: Xinli Zhang, Jue Lu, Xiaoming Liu, Peng Sun, Qian Qin, Zhengdong Xiang, Lan Cheng, Xiaoxiao Zhang, Xiaotong Guo, Jing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
glioma
IDH
1p/19q codeletion
MGMT
pH assessment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1507335/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1507335/full

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