H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation

H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation

Abstract Background N-terminal acetylation (Nt-Ac), mediated by N-terminal acetyltransferases (NATs) is one of the most abundant protein modifications occurring approximately in 80% of all eukaryotic proteins. In contrast to the broad spectrum NATs, the human N-alpha-acetyltransferase 40 (NAA40) is...

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Bibliographic Details
Main Authors: Ariel Klavaris, Costas Koufaris, Roberta Noberini, Maria Kouma, Christina Demetriadou, Alessandro Ghiringhelli, Nikolas Dietis, Tiziana Bonaldi, Antonis Kirmizis
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Epigenetics & Chromatin
Subjects:
NAA40
H2A.X
Acetylation
Chromatin
Epigenetics
Histone
Online Access:https://doi.org/10.1186/s13072-025-00608-3
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