HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice
Abstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mic...
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2025-06-01
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| Online Access: | https://doi.org/10.14814/phy2.70409 |
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| author | Saeed Niazmand S. A. Rahim Rezaee Jamshid Gholizadeh Navashenaq Nema Mohamadian Roshan Mohsen Ghoryani Houshang Rafatpanah Maryam Mahmoudabady Yousef Baghcheghi Maryam Paseban Mahdiyeh Hedayati‐Moghadam |
| author_facet | Saeed Niazmand S. A. Rahim Rezaee Jamshid Gholizadeh Navashenaq Nema Mohamadian Roshan Mohsen Ghoryani Houshang Rafatpanah Maryam Mahmoudabady Yousef Baghcheghi Maryam Paseban Mahdiyeh Hedayati‐Moghadam |
| author_sort | Saeed Niazmand |
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| description | Abstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mice. Twenty BALB/c mice were divided into two groups: the HTLV‐1‐infected group and the control group. Two months later, samples were collected from blood, aorta, heart, spleen, and lymph nodes. Finally, the levels of various plasma markers (lipid profile, creatine phosphokinase, nitric oxide, GSH, and total thiol), oxidative stress markers (SOD and CAT activity, MDA and total thiol levels), chemokine receptors genes expression (CCR2, CXCR2, CCR1) and eNOS expression in aortic and heart tissues, as well as histopathological changes in the heart, were evaluated. Plasma triglyceride, creatine phosphokinase, nitric oxide, and aorta malondialdehyde levels in the HTLV‐1‐infected group were higher than those in the control group. In contrast, total thiol levels in plasma, heart, and aorta, plasma glutathione levels, and the activities of superoxide dismutase and catalase were lower compared to the control group. The expression of CCR2 and CXCR2 was elevated in the aorta of the HTLV‐1‐infected group, while eNOS expression was reduced in both aortic and heart tissues. HTLV‐1 may contribute to inflammatory responses and oxidative stress in cardiovascular tissues. |
| format | Article |
| id | doaj-art-1110fa7433904f9baebc620ad7935a23 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | Physiological Reports |
| spelling | doaj-art-1110fa7433904f9baebc620ad7935a232025-08-20T03:45:10ZengWileyPhysiological Reports2051-817X2025-06-011311n/an/a10.14814/phy2.70409HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male miceSaeed Niazmand0S. A. Rahim Rezaee1Jamshid Gholizadeh Navashenaq2Nema Mohamadian Roshan3Mohsen Ghoryani4Houshang Rafatpanah5Maryam Mahmoudabady6Yousef Baghcheghi7Maryam Paseban8Mahdiyeh Hedayati‐Moghadam9Department of Physiology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad IranImmunology Research Center, Inflammation and Inflammatory Diseases Division Mashhad University of Medical Sciences Mashhad IranNoncommunicable Diseases Research Center Bam University of Medical Sciences Bam IranDepartment of Pathology, Ghaem Hospital Mashhad University of Medical Sciences Mashhad IranDepartment of Laboratory Sciences, School of Paramedical Sciences Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh IranImmunology Research Center, Inflammation and Inflammatory Diseases Division Mashhad University of Medical Sciences Mashhad IranDepartment of Physiology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad IranBio Environmental Health Hazards Research Center Jiroft University of Medical Sciences Jiroft IranInnovative Medical Research Center and Department of Physiology, Faculty of Medicine Mashhad Medical Science Islamic Azad University Mashhad IranStudent Research Committee Jiroft University of Medical Sciences Jiroft IranAbstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mice. Twenty BALB/c mice were divided into two groups: the HTLV‐1‐infected group and the control group. Two months later, samples were collected from blood, aorta, heart, spleen, and lymph nodes. Finally, the levels of various plasma markers (lipid profile, creatine phosphokinase, nitric oxide, GSH, and total thiol), oxidative stress markers (SOD and CAT activity, MDA and total thiol levels), chemokine receptors genes expression (CCR2, CXCR2, CCR1) and eNOS expression in aortic and heart tissues, as well as histopathological changes in the heart, were evaluated. Plasma triglyceride, creatine phosphokinase, nitric oxide, and aorta malondialdehyde levels in the HTLV‐1‐infected group were higher than those in the control group. In contrast, total thiol levels in plasma, heart, and aorta, plasma glutathione levels, and the activities of superoxide dismutase and catalase were lower compared to the control group. The expression of CCR2 and CXCR2 was elevated in the aorta of the HTLV‐1‐infected group, while eNOS expression was reduced in both aortic and heart tissues. HTLV‐1 may contribute to inflammatory responses and oxidative stress in cardiovascular tissues.https://doi.org/10.14814/phy2.70409aortaheartHTLV‐1inflammationoxidative stress |
| spellingShingle | Saeed Niazmand S. A. Rahim Rezaee Jamshid Gholizadeh Navashenaq Nema Mohamadian Roshan Mohsen Ghoryani Houshang Rafatpanah Maryam Mahmoudabady Yousef Baghcheghi Maryam Paseban Mahdiyeh Hedayati‐Moghadam HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice Physiological Reports aorta heart HTLV‐1 inflammation oxidative stress |
| title | HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice |
| title_full | HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice |
| title_fullStr | HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice |
| title_full_unstemmed | HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice |
| title_short | HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice |
| title_sort | htlv 1 infection altered expression of ccr2 cxcr2 enos genes and oxidative stress in aorta and heart of male mice |
| topic | aorta heart HTLV‐1 inflammation oxidative stress |
| url | https://doi.org/10.14814/phy2.70409 |
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