A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine

A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine

ObjectiveAcetylcholine modulates the activity of the direct and indirect pathways within the striatum through interaction with muscarinic M4 and M1 receptors. M4 receptors are uniquely positioned to regulate plasticity within the direct pathway and play a substantial role in reward and addiction-rel...

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Bibliographic Details
Main Authors: Anna Berezovskaia, Morgan Thomsen, Anders Fink-Jensen, Gitta Wörtwein
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
acetylcholine
cholinergic receptor muscarinic 4
cocaine
ChAT(BAC)-Cre
autoreceptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1451010/full
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