Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis
Meningitis due to resistant microorganisms after neurosurgical intervention progresses with significant morbidity and mortality. Treatment is difficult as the antibiotics available for this purpose as well as their transition to the cerebrospinal fluid are limited. Due to the inability of the intra...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2022-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/14096 |
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| author | Merve İşeri Nepesov Ömer Kılıç Ener Çağrı Dinleyici |
| author_facet | Merve İşeri Nepesov Ömer Kılıç Ener Çağrı Dinleyici |
| author_sort | Merve İşeri Nepesov |
| collection | DOAJ |
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Meningitis due to resistant microorganisms after neurosurgical intervention progresses with significant morbidity and mortality. Treatment is difficult as the antibiotics available for this purpose as well as their transition to the cerebrospinal fluid are limited. Due to the inability of the intravenously administered colistin to cross the blood–brain barrier sufficiently, intraventricular colistin application is recommended in the treatment of meningitis. Herein we report successful treatment with intraventricular colistin of an infant with ventriculoperitoneal shunt-related meningitis due to extended spectrum β-lactamase-producing Klebsiella pneumoniae. The infant lacked clinical response despite effective intravenous antibiotic therapy. Intrathecal/intraventricular colistin can be an effective alternative in the treatment of resistant Gram-negative bacilli meningitis.
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| format | Article |
| id | doaj-art-10fee6f4f16242ab874e42e983065e18 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-10fee6f4f16242ab874e42e983065e182025-08-20T02:27:07ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-07-01160710.3855/jidc.14096Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitisMerve İşeri Nepesov0Ömer Kılıç1Ener Çağrı Dinleyici2Department of Pediatrics, Division of Pediatric Infectious Disease, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, TurkeyDepartment of Pediatrics, Division of Pediatric Infectious Disease, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, TurkeyDepartment of Pediatrics, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey Meningitis due to resistant microorganisms after neurosurgical intervention progresses with significant morbidity and mortality. Treatment is difficult as the antibiotics available for this purpose as well as their transition to the cerebrospinal fluid are limited. Due to the inability of the intravenously administered colistin to cross the blood–brain barrier sufficiently, intraventricular colistin application is recommended in the treatment of meningitis. Herein we report successful treatment with intraventricular colistin of an infant with ventriculoperitoneal shunt-related meningitis due to extended spectrum β-lactamase-producing Klebsiella pneumoniae. The infant lacked clinical response despite effective intravenous antibiotic therapy. Intrathecal/intraventricular colistin can be an effective alternative in the treatment of resistant Gram-negative bacilli meningitis. https://jidc.org/index.php/journal/article/view/14096Klebsiellameningitisantimicrobial resistanceintraventricular colistin |
| spellingShingle | Merve İşeri Nepesov Ömer Kılıç Ener Çağrı Dinleyici Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis Journal of Infection in Developing Countries Klebsiella meningitis antimicrobial resistance intraventricular colistin |
| title | Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis |
| title_full | Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis |
| title_fullStr | Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis |
| title_full_unstemmed | Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis |
| title_short | Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis |
| title_sort | successful intraventricular colistin treatment in resistant klebsiella pneumoniae meningitis |
| topic | Klebsiella meningitis antimicrobial resistance intraventricular colistin |
| url | https://jidc.org/index.php/journal/article/view/14096 |
| work_keys_str_mv | AT merveiserinepesov successfulintraventricularcolistintreatmentinresistantklebsiellapneumoniaemeningitis AT omerkılıc successfulintraventricularcolistintreatmentinresistantklebsiellapneumoniaemeningitis AT enercagrıdinleyici successfulintraventricularcolistintreatmentinresistantklebsiellapneumoniaemeningitis |