Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder
Background: Childhood maltreatment (CM) is associated with negative mental health outcomes. Many studies conceptualize resilience as experiencing CM without developing psychopathology (primary resilience). However, some people may develop subsequent psychopathology but recover and demonstrate higher...
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Elsevier
2025-05-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174325000333 |
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| author | Mindy Westlund Schreiner Leah R. Thomas Ha D.H. Le Myah Pazdera Daniel A. Feldman Brian Farstead Katie L. Bessette Robert C. Welsh Sheila E. Crowell Erin A. Kaufman Heide Klumpp Scott A. Langenecker |
| author_facet | Mindy Westlund Schreiner Leah R. Thomas Ha D.H. Le Myah Pazdera Daniel A. Feldman Brian Farstead Katie L. Bessette Robert C. Welsh Sheila E. Crowell Erin A. Kaufman Heide Klumpp Scott A. Langenecker |
| author_sort | Mindy Westlund Schreiner |
| collection | DOAJ |
| description | Background: Childhood maltreatment (CM) is associated with negative mental health outcomes. Many studies conceptualize resilience as experiencing CM without developing psychopathology (primary resilience). However, some people may develop subsequent psychopathology but recover and demonstrate higher global functioning (secondary resilience). This study investigated the role of salience and emotion network (SEN) (including the amygdala, subgenual anterior cingulate cortex, and anterior insula) and cognitive control network (CCN) (including the dorsolateral prefrontal cortex, inferior parietal lobule, and thalamus) connectivity in primary and secondary resilience. Methods: We examined resting-state functional connectivity in 108 nonclinical control participants and 154 individuals with any mood disorder (AMD). We measured functioning and CM using the Global Assessment of Functioning (GAF) scale and the Childhood Trauma Questionnaire (CTQ), respectively. For primary resilience, we conducted whole-brain analyses of SEN and CCN regions to test for group × CTQ interactions. For secondary resilience, within-AMD group analyses tested for CTQ × GAF interactions. Results: Group × CTQ interactions revealed that control participants with higher levels of CM showed greater within-SEN and within-CCN connectivity than participants in the AMD group. In the AMD group, participants with higher levels of CM and functioning (secondary resilience) showed greater within-CCN connectivity while participants with higher levels of CM and lower functioning showed greater within-SEN connectivity. Conclusions: Greater SEN connectivity appears to play a key role in primary resilience, as observed in the control group, but only within the context of greater CCN connectivity. Future work should explore which cognitive control features are most beneficial and whether targeted interventions help foster resilience to recurrent psychopathology. |
| format | Article |
| id | doaj-art-10f59068486e4a259f77b7e384dff65a |
| institution | OA Journals |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-10f59068486e4a259f77b7e384dff65a2025-08-20T02:08:34ZengElsevierBiological Psychiatry Global Open Science2667-17432025-05-015310047910.1016/j.bpsgos.2025.100479Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood DisorderMindy Westlund Schreiner0Leah R. Thomas1Ha D.H. Le2Myah Pazdera3Daniel A. Feldman4Brian Farstead5Katie L. Bessette6Robert C. Welsh7Sheila E. Crowell8Erin A. Kaufman9Heide Klumpp10Scott A. Langenecker11Department of Behavioral Health, Nationwide Children’s Hospital, Columbus, Ohio; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio; Address correspondence to Mindy Westlund Schreiner, Ph.D.Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio; Department of Psychology and Child Development, California Polytechnic State University, San Luis Obispo, CaliforniaDepartment of Pediatrics, University of California San Francisco, San Francisco, CaliforniaDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UtahDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah; Department of Biomedical Engineering, University of Utah, Salt Lake City, UtahDepartment of Psychology, University of Southern Mississippi, Hattiesburg, HattiesburgDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CaliforniaDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CaliforniaDepartment of Psychology, University of Oregon, Eugene, OregonDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UtahDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IllinoisDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OhioBackground: Childhood maltreatment (CM) is associated with negative mental health outcomes. Many studies conceptualize resilience as experiencing CM without developing psychopathology (primary resilience). However, some people may develop subsequent psychopathology but recover and demonstrate higher global functioning (secondary resilience). This study investigated the role of salience and emotion network (SEN) (including the amygdala, subgenual anterior cingulate cortex, and anterior insula) and cognitive control network (CCN) (including the dorsolateral prefrontal cortex, inferior parietal lobule, and thalamus) connectivity in primary and secondary resilience. Methods: We examined resting-state functional connectivity in 108 nonclinical control participants and 154 individuals with any mood disorder (AMD). We measured functioning and CM using the Global Assessment of Functioning (GAF) scale and the Childhood Trauma Questionnaire (CTQ), respectively. For primary resilience, we conducted whole-brain analyses of SEN and CCN regions to test for group × CTQ interactions. For secondary resilience, within-AMD group analyses tested for CTQ × GAF interactions. Results: Group × CTQ interactions revealed that control participants with higher levels of CM showed greater within-SEN and within-CCN connectivity than participants in the AMD group. In the AMD group, participants with higher levels of CM and functioning (secondary resilience) showed greater within-CCN connectivity while participants with higher levels of CM and lower functioning showed greater within-SEN connectivity. Conclusions: Greater SEN connectivity appears to play a key role in primary resilience, as observed in the control group, but only within the context of greater CCN connectivity. Future work should explore which cognitive control features are most beneficial and whether targeted interventions help foster resilience to recurrent psychopathology.http://www.sciencedirect.com/science/article/pii/S2667174325000333Child maltreatmentCognitive control networkMood disordersResilienceResting-state functional connectivitySalience and emotion network |
| spellingShingle | Mindy Westlund Schreiner Leah R. Thomas Ha D.H. Le Myah Pazdera Daniel A. Feldman Brian Farstead Katie L. Bessette Robert C. Welsh Sheila E. Crowell Erin A. Kaufman Heide Klumpp Scott A. Langenecker Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder Biological Psychiatry Global Open Science Child maltreatment Cognitive control network Mood disorders Resilience Resting-state functional connectivity Salience and emotion network |
| title | Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder |
| title_full | Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder |
| title_fullStr | Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder |
| title_full_unstemmed | Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder |
| title_short | Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder |
| title_sort | identifying features of resilience to childhood maltreatment in resting state connectivity data from adults with and without a history of mood disorder |
| topic | Child maltreatment Cognitive control network Mood disorders Resilience Resting-state functional connectivity Salience and emotion network |
| url | http://www.sciencedirect.com/science/article/pii/S2667174325000333 |
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