17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach
B-cell small lymphocytic lymphoma (B-SLL) belongs to the category of indolent non-Hodgkin's lymphomas and is defined by the proliferation of mature, inert B lymphocytes and their accumulation in lymphoid structures. Although it is classified as the same entity as chronic lymphocytic leukemia (B...
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Romanian Society of Hematology
2025-03-01
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| Series: | Documenta Haematologica |
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| Online Access: | https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art2.pdf |
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| author | Andreea-Georgiana STOICA Miruna CRISTIAN Mariana ASCHIE Anca-Florentina MITROI Georgiana-Camelia COZARU Gabriela-Izabela BALTATESCU Madalina BOSOTEANU Mihaela-Maria GHINEA |
| author_facet | Andreea-Georgiana STOICA Miruna CRISTIAN Mariana ASCHIE Anca-Florentina MITROI Georgiana-Camelia COZARU Gabriela-Izabela BALTATESCU Madalina BOSOTEANU Mihaela-Maria GHINEA |
| author_sort | Andreea-Georgiana STOICA |
| collection | DOAJ |
| description | B-cell small lymphocytic lymphoma (B-SLL) belongs to the category of indolent non-Hodgkin's lymphomas and is defined by the proliferation of mature, inert B lymphocytes and their accumulation in lymphoid structures. Although it is classified as the same entity as chronic lymphocytic leukemia (B-CLL), according to the World Health Organization and the International B-CLL Task Force [1, 2], there is little data on the management of lymphocytic lymphoma, accounting for only 10-15% of B-CLL/SLL cases [3, 4]. The aim of this study is to evaluate the presence of the 17p13.1 deletion in a series of "pure" lymphocytic lymphoma cases from 2017-2020, given that it is considered an identical entity to chronic lymphocytic leukemia. It is known that del17p13.1 provides resistance to chemotherapy and is a negative prognostic factor in B-CLL, but its routine evaluation is not routinely performed in practice as part of B-SLL diagnosis. Our findings highlight the contribution of del17p13.1 identification in patients diagnosed with B-SLL, enhancing diagnostic accuracy and treatment management efficiency, suggesting its potential as a standard diagnostic tool in clinical settings. The review aims to provide a comprehensive overview for hematologists and pathologists, encouraging the adoption of del17p13.1 identification to improve patient outcomes in the management of B-SLL. |
| format | Article |
| id | doaj-art-10f56594efec423cbceb3d3ed5cfa78b |
| institution | OA Journals |
| issn | 3008-220X 2972-242X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Romanian Society of Hematology |
| record_format | Article |
| series | Documenta Haematologica |
| spelling | doaj-art-10f56594efec423cbceb3d3ed5cfa78b2025-08-20T02:20:10ZengRomanian Society of HematologyDocumenta Haematologica3008-220X2972-242X2025-03-0131111710.59854/dhrrh.2025.3.1.1117p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic ApproachAndreea-Georgiana STOICA0Miruna CRISTIAN1https://orcid.org/0000-0001-5191-2585Mariana ASCHIE2https://orcid.org/0000-0002-4255-586XAnca-Florentina MITROI3Georgiana-Camelia COZARU4Gabriela-Izabela BALTATESCU5Madalina BOSOTEANU6Mihaela-Maria GHINEA7Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology - CEDMOG, "Ovidius" University of Constanta, Constanta, RomaniaCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology - CEDMOG, "Ovidius" University of Constanta, Constanta, RomaniaFaculty of Medicine, "Ovidius" University of Constanta, Constanta, RomaniaCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology - CEDMOG, "Ovidius" University of Constanta, Constanta, RomaniaCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology - CEDMOG, "Ovidius" University of Constanta, Constanta, RomaniaCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology - CEDMOG, "Ovidius" University of Constanta, Constanta, RomaniaFaculty of Medicine, "Ovidius" University of Constanta, Constanta, RomaniaFaculty of Medicine, "Ovidius" University of Constanta, Constanta, RomaniaB-cell small lymphocytic lymphoma (B-SLL) belongs to the category of indolent non-Hodgkin's lymphomas and is defined by the proliferation of mature, inert B lymphocytes and their accumulation in lymphoid structures. Although it is classified as the same entity as chronic lymphocytic leukemia (B-CLL), according to the World Health Organization and the International B-CLL Task Force [1, 2], there is little data on the management of lymphocytic lymphoma, accounting for only 10-15% of B-CLL/SLL cases [3, 4]. The aim of this study is to evaluate the presence of the 17p13.1 deletion in a series of "pure" lymphocytic lymphoma cases from 2017-2020, given that it is considered an identical entity to chronic lymphocytic leukemia. It is known that del17p13.1 provides resistance to chemotherapy and is a negative prognostic factor in B-CLL, but its routine evaluation is not routinely performed in practice as part of B-SLL diagnosis. Our findings highlight the contribution of del17p13.1 identification in patients diagnosed with B-SLL, enhancing diagnostic accuracy and treatment management efficiency, suggesting its potential as a standard diagnostic tool in clinical settings. The review aims to provide a comprehensive overview for hematologists and pathologists, encouraging the adoption of del17p13.1 identification to improve patient outcomes in the management of B-SLL.https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art2.pdfsmall b-cell lymphocytic lymphomadel17p13.1 |
| spellingShingle | Andreea-Georgiana STOICA Miruna CRISTIAN Mariana ASCHIE Anca-Florentina MITROI Georgiana-Camelia COZARU Gabriela-Izabela BALTATESCU Madalina BOSOTEANU Mihaela-Maria GHINEA 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach Documenta Haematologica small b-cell lymphocytic lymphoma del17p13.1 |
| title | 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach |
| title_full | 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach |
| title_fullStr | 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach |
| title_full_unstemmed | 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach |
| title_short | 17p13.1 Deletion in Small B-cell Lymphocytic Lymphomas: A Prognostic Factor and Diagnostic Approach |
| title_sort | 17p13 1 deletion in small b cell lymphocytic lymphomas a prognostic factor and diagnostic approach |
| topic | small b-cell lymphocytic lymphoma del17p13.1 |
| url | https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art2.pdf |
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