Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey.
<h4>Background</h4>The burden of dyslipidaemia is rising in many low income countries. However, there are few data on the prevalence of, or risk factors for, dyslipidaemia in Africa.<h4>Methods</h4>In 2011, we used the WHO Stepwise approach to collect cardiovascular risk data...
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Public Library of Science (PLoS)
2015-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0126166 |
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| author | Gershim Asiki Georgina A V Murphy Kathy Baisley Rebecca N Nsubuga Alex Karabarinde Robert Newton Janet Seeley Elizabeth H Young Anatoli Kamali Manjinder S Sandhu |
| author_facet | Gershim Asiki Georgina A V Murphy Kathy Baisley Rebecca N Nsubuga Alex Karabarinde Robert Newton Janet Seeley Elizabeth H Young Anatoli Kamali Manjinder S Sandhu |
| author_sort | Gershim Asiki |
| collection | DOAJ |
| description | <h4>Background</h4>The burden of dyslipidaemia is rising in many low income countries. However, there are few data on the prevalence of, or risk factors for, dyslipidaemia in Africa.<h4>Methods</h4>In 2011, we used the WHO Stepwise approach to collect cardiovascular risk data within a general population cohort in rural south-western Uganda. Dyslipidaemia was defined by high total cholesterol (TC) ≥ 5.2 mmol/L or low high density lipoprotein cholesterol (HDL-C) <1 mmol/L in men, and <1.3 mmol/L in women. Logistic regression was used to explore correlates of dyslipidaemia.<h4>Results</h4>Low HDL-C prevalence was 71.3% and high TC was 6.0%. In multivariate analysis, factors independently associated with low HDL-C among both men and women were: decreasing age, tribe (prevalence highest among Rwandese tribe), lower education, alcohol consumption (comparing current drinkers to never drinkers: men adjusted (a)OR=0.44, 95%CI=0.35-0.55; women aOR=0.51, 95%CI=0.41-0.64), consuming <5 servings of fruit/vegetable per day, daily vigorous physical activity (comparing those with none vs those with 5 days a week: men aOR=0.83 95%CI=0.67-1.02; women aOR=0.76, 95%CI=0.55-0.99), blood pressure (comparing those with hypertension to those with normal blood pressure: men aOR=0.57, 95%CI=0.43-0.75; women aOR=0.69, 95%CI=0.52-0.93) and HIV infection (HIV infected without ART vs. HIV negative: men aOR=2.45, 95%CI=1.53-3.94; women aOR=1.88, 95%CI=1.19-2.97). The odds of low HDL-C was also higher among men with high BMI or HbA1c ≤ 6%, and women who were single or with abdominal obesity. Among both men and women, high TC was independently associated with increasing age, non-Rwandese tribe, high waist circumference (men aOR=5.70, 95%CI=1.97-16.49; women aOR=1.58, 95%CI=1.10-2.28), hypertension (men aOR=3.49, 95%CI=1.74-7.00; women aOR=1.47, 95%CI=0.96-2.23) and HbA1c >6% (men aOR=3.00, 95%CI=1.37-6.59; women aOR=2.74, 95%CI=1.77-4.27). The odds of high TC was also higher among married men, and women with higher education or high BMI.<h4>Conclusion</h4>Low HDL-C prevalence in this relatively young rural population is high whereas high TC prevalence is low. The consequences of dyslipidaemia in African populations remain unclear and prospective follow-up is required. |
| format | Article |
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| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
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| spelling | doaj-art-10e8ae66afe64a98b006c862bfeeab5a2025-08-20T02:22:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012616610.1371/journal.pone.0126166Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey.Gershim AsikiGeorgina A V MurphyKathy BaisleyRebecca N NsubugaAlex KarabarindeRobert NewtonJanet SeeleyElizabeth H YoungAnatoli KamaliManjinder S Sandhu<h4>Background</h4>The burden of dyslipidaemia is rising in many low income countries. However, there are few data on the prevalence of, or risk factors for, dyslipidaemia in Africa.<h4>Methods</h4>In 2011, we used the WHO Stepwise approach to collect cardiovascular risk data within a general population cohort in rural south-western Uganda. Dyslipidaemia was defined by high total cholesterol (TC) ≥ 5.2 mmol/L or low high density lipoprotein cholesterol (HDL-C) <1 mmol/L in men, and <1.3 mmol/L in women. Logistic regression was used to explore correlates of dyslipidaemia.<h4>Results</h4>Low HDL-C prevalence was 71.3% and high TC was 6.0%. In multivariate analysis, factors independently associated with low HDL-C among both men and women were: decreasing age, tribe (prevalence highest among Rwandese tribe), lower education, alcohol consumption (comparing current drinkers to never drinkers: men adjusted (a)OR=0.44, 95%CI=0.35-0.55; women aOR=0.51, 95%CI=0.41-0.64), consuming <5 servings of fruit/vegetable per day, daily vigorous physical activity (comparing those with none vs those with 5 days a week: men aOR=0.83 95%CI=0.67-1.02; women aOR=0.76, 95%CI=0.55-0.99), blood pressure (comparing those with hypertension to those with normal blood pressure: men aOR=0.57, 95%CI=0.43-0.75; women aOR=0.69, 95%CI=0.52-0.93) and HIV infection (HIV infected without ART vs. HIV negative: men aOR=2.45, 95%CI=1.53-3.94; women aOR=1.88, 95%CI=1.19-2.97). The odds of low HDL-C was also higher among men with high BMI or HbA1c ≤ 6%, and women who were single or with abdominal obesity. Among both men and women, high TC was independently associated with increasing age, non-Rwandese tribe, high waist circumference (men aOR=5.70, 95%CI=1.97-16.49; women aOR=1.58, 95%CI=1.10-2.28), hypertension (men aOR=3.49, 95%CI=1.74-7.00; women aOR=1.47, 95%CI=0.96-2.23) and HbA1c >6% (men aOR=3.00, 95%CI=1.37-6.59; women aOR=2.74, 95%CI=1.77-4.27). The odds of high TC was also higher among married men, and women with higher education or high BMI.<h4>Conclusion</h4>Low HDL-C prevalence in this relatively young rural population is high whereas high TC prevalence is low. The consequences of dyslipidaemia in African populations remain unclear and prospective follow-up is required.https://doi.org/10.1371/journal.pone.0126166 |
| spellingShingle | Gershim Asiki Georgina A V Murphy Kathy Baisley Rebecca N Nsubuga Alex Karabarinde Robert Newton Janet Seeley Elizabeth H Young Anatoli Kamali Manjinder S Sandhu Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. PLoS ONE |
| title | Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. |
| title_full | Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. |
| title_fullStr | Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. |
| title_full_unstemmed | Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. |
| title_short | Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey. |
| title_sort | prevalence of dyslipidaemia and associated risk factors in a rural population in south western uganda a community based survey |
| url | https://doi.org/10.1371/journal.pone.0126166 |
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