Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications
Targeted Alpha Therapy treatments using astatine-211 (211At) is being studied as a promising method for cancer treatment, and gold nanoparticles have been studied as one of the promising carriers to deliver astatine to the target area. Since there are other promising metals that can be used for biom...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Next Nanotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829525001007 |
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| author | Jeffrey Tanudji Hideaki Kasai Michio Okada Hiroshi Nakanishi |
| author_facet | Jeffrey Tanudji Hideaki Kasai Michio Okada Hiroshi Nakanishi |
| author_sort | Jeffrey Tanudji |
| collection | DOAJ |
| description | Targeted Alpha Therapy treatments using astatine-211 (211At) is being studied as a promising method for cancer treatment, and gold nanoparticles have been studied as one of the promising carriers to deliver astatine to the target area. Since there are other promising metals that can be used for biomedical purposes, we started by looking at the feasibility of improving the flexibility of such methodology by performing a theoretical study on the adsorption of astatine on different noble metals. We thus considered platinum, silver, and copper as potential materials for carriers, and compare their adsorption characteristics of astatine to gold. We found the adsorption strength of astatine on platinum to be superior to the other metals studied. The analysis based on charge densities and electronic states lead us to conclude that adsorption strength depends the level of electronic filling of the metals’ valence orbitals. Considering that the platinum 5d orbital is partially filled, it allows for a stronger adsorption of astatine on its surface, compared to the other three fully-filled metals. We hope this study can galvanize interest in other metallic materials being considered in the future, to allow for a more robust methodology. |
| format | Article |
| id | doaj-art-10e89bcc90d14a96ae2e6f3c6342d9c2 |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-10e89bcc90d14a96ae2e6f3c6342d9c22025-08-20T03:36:18ZengElsevierNext Nanotechnology2949-82952025-01-01810023110.1016/j.nxnano.2025.100231Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applicationsJeffrey Tanudji0Hideaki Kasai1Michio Okada2Hiroshi Nakanishi3Institute of Radiation Sciences, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanInstitute of Radiation Sciences, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan; Department of Applied Physics, Faculty of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; National Institute of Technology, Akashi College, 679-3 Nishioka, Uozumi-cho, Akashi, Hyogo 674-8501, Japan; Corresponding author at: Institute of Radiation Sciences, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.Institute of Radiation Sciences, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan; Department of Chemistry, Faculty of Science, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, JapanNational Institute of Technology, Akashi College, 679-3 Nishioka, Uozumi-cho, Akashi, Hyogo 674-8501, JapanTargeted Alpha Therapy treatments using astatine-211 (211At) is being studied as a promising method for cancer treatment, and gold nanoparticles have been studied as one of the promising carriers to deliver astatine to the target area. Since there are other promising metals that can be used for biomedical purposes, we started by looking at the feasibility of improving the flexibility of such methodology by performing a theoretical study on the adsorption of astatine on different noble metals. We thus considered platinum, silver, and copper as potential materials for carriers, and compare their adsorption characteristics of astatine to gold. We found the adsorption strength of astatine on platinum to be superior to the other metals studied. The analysis based on charge densities and electronic states lead us to conclude that adsorption strength depends the level of electronic filling of the metals’ valence orbitals. Considering that the platinum 5d orbital is partially filled, it allows for a stronger adsorption of astatine on its surface, compared to the other three fully-filled metals. We hope this study can galvanize interest in other metallic materials being considered in the future, to allow for a more robust methodology.http://www.sciencedirect.com/science/article/pii/S2949829525001007Astatine adsorption on metal substratesDrug delivery designTheoretical materials design |
| spellingShingle | Jeffrey Tanudji Hideaki Kasai Michio Okada Hiroshi Nakanishi Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications Next Nanotechnology Astatine adsorption on metal substrates Drug delivery design Theoretical materials design |
| title | Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| title_full | Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| title_fullStr | Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| title_full_unstemmed | Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| title_short | Theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| title_sort | theoretical study in comparison of astatine adsorptions on metal carrier materials for targeted alpha therapy applications |
| topic | Astatine adsorption on metal substrates Drug delivery design Theoretical materials design |
| url | http://www.sciencedirect.com/science/article/pii/S2949829525001007 |
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