Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core
Heterocyclic compounds are the cornerstone for active pharmaceutical ingredients. Among heterocycles, isoindoline core occupies a special place, as ten commercial bioactive compounds/drugs contain this skeleton decorated with several functional groups required for optimal receptor binding. These dru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Organics |
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| Online Access: | https://www.mdpi.com/2673-401X/6/1/3 |
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| _version_ | 1849341265265557504 |
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| author | Mukund Jha Dani Youssef Haley Sheehy Amitabh Jha |
| author_facet | Mukund Jha Dani Youssef Haley Sheehy Amitabh Jha |
| author_sort | Mukund Jha |
| collection | DOAJ |
| description | Heterocyclic compounds are the cornerstone for active pharmaceutical ingredients. Among heterocycles, isoindoline core occupies a special place, as ten commercial bioactive compounds/drugs contain this skeleton decorated with several functional groups required for optimal receptor binding. These drugs are employed for indications such as multiple myeloma, leukemia, inflammation, hypertension, edema, obesity, and insect control. This review presents the pharmacological activities, mechanisms of action, and chemical syntheses of these commercial bioactive molecules/drugs. |
| format | Article |
| id | doaj-art-10e451f9014f40c9a4fec651bdc8be03 |
| institution | Kabale University |
| issn | 2673-401X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Organics |
| spelling | doaj-art-10e451f9014f40c9a4fec651bdc8be032025-08-20T03:43:40ZengMDPI AGOrganics2673-401X2025-01-0161310.3390/org6010003Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle CoreMukund Jha0Dani Youssef1Haley Sheehy2Amitabh Jha3Department of Biology, Chemistry and Geography, Nipissing University, North Bay, ON P1B 8L7, CanadaDépartement des Sciences, Université Sainte Anne, Church Point, NS B0W 1M0, CanadaDepartment of Chemistry, Acadia University, Wolfville, NS B4P 2R6, CanadaDepartment of Chemistry, Acadia University, Wolfville, NS B4P 2R6, CanadaHeterocyclic compounds are the cornerstone for active pharmaceutical ingredients. Among heterocycles, isoindoline core occupies a special place, as ten commercial bioactive compounds/drugs contain this skeleton decorated with several functional groups required for optimal receptor binding. These drugs are employed for indications such as multiple myeloma, leukemia, inflammation, hypertension, edema, obesity, and insect control. This review presents the pharmacological activities, mechanisms of action, and chemical syntheses of these commercial bioactive molecules/drugs.https://www.mdpi.com/2673-401X/6/1/3isoindolineheterocyclesclinical drugspharmacologyisoindoline-based thalidomideimide drugs |
| spellingShingle | Mukund Jha Dani Youssef Haley Sheehy Amitabh Jha Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core Organics isoindoline heterocycles clinical drugs pharmacology isoindoline-based thalidomide imide drugs |
| title | Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core |
| title_full | Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core |
| title_fullStr | Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core |
| title_full_unstemmed | Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core |
| title_short | Synthesis and Pharmacology of Clinical Drugs Containing Isoindoline Heterocycle Core |
| title_sort | synthesis and pharmacology of clinical drugs containing isoindoline heterocycle core |
| topic | isoindoline heterocycles clinical drugs pharmacology isoindoline-based thalidomide imide drugs |
| url | https://www.mdpi.com/2673-401X/6/1/3 |
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