The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia
Abstract Background/aims The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals with hyperuricemia is significantly high. The aim of this study was to identify effective biomarkers for the detection of MASLD among patients with hyperuricemia. Method We co...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03786-2 |
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| author | Qian-Qian Wang Ning Zhang Xiang Xu Si-Ang Lv Zhuo-Deng Huang Xi-Dai Long Jun Wu |
| author_facet | Qian-Qian Wang Ning Zhang Xiang Xu Si-Ang Lv Zhuo-Deng Huang Xi-Dai Long Jun Wu |
| author_sort | Qian-Qian Wang |
| collection | DOAJ |
| description | Abstract Background/aims The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals with hyperuricemia is significantly high. The aim of this study was to identify effective biomarkers for the detection of MASLD among patients with hyperuricemia. Method We conducted an analysis involving 3424 participants with hyperuricemia from the National Health and Nutrition Examination Survey (1999–2020). To identify potential significant variables, we employed Boruta's algorithm, SHapley Additive exPlanations (SHAP) and random forests. Multivariable logistic regression models were utilized to assess the odds ratio (OR) of developing MASLD. To evaluate the accuracy and clinical value of our prediction model, we employed receiver operating characteristic (ROC) curves and decision curve analysis (DCA) curves. Results Among the study population of 3424 participants (mean [SD] age, 54 [20] years, 1788 [52.22%] males) with hyperuricemia, 1670 participants had MASLD. Using Boruta's algorithm, SHAP and random forests, our analysis suggested that Triglyceride Glucose-Waist Circumference (TyG_WC) was one of the most significant variables in predicting MASLD risk, with an area under the receiver operating characteristic (AUROC) of 0.865. The restricted curve spline (RCS) revealed a positive association between the odds ratio of TyG_WC and MASLD, when compared with lowest quantile of TyG_WC, the risk of MASLD for highest quantile was 137.96 times higher. The predictive strategy incorporating TyG_WC notably enhanced the clinical model, with threshold probabilities spanning from approximately 0% to 100%, resulting in a significant improvement of the net benefit. Conclusions Our analysis found that TyG_WC was one of the most significant variables in predicting MASLD risk among individuals with hyperuricemia. |
| format | Article |
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| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-10de9b173b3d45fd98e25af2dbc016b52025-08-20T03:07:41ZengBMCBMC Gastroenterology1471-230X2025-04-0125111210.1186/s12876-025-03786-2The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemiaQian-Qian Wang0Ning Zhang1Xiang Xu2Si-Ang Lv3Zhuo-Deng Huang4Xi-Dai Long5Jun Wu6Department of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pathology, the Affiliated Hospital of Youjiang Medical University for NationalitiesDepartment of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background/aims The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals with hyperuricemia is significantly high. The aim of this study was to identify effective biomarkers for the detection of MASLD among patients with hyperuricemia. Method We conducted an analysis involving 3424 participants with hyperuricemia from the National Health and Nutrition Examination Survey (1999–2020). To identify potential significant variables, we employed Boruta's algorithm, SHapley Additive exPlanations (SHAP) and random forests. Multivariable logistic regression models were utilized to assess the odds ratio (OR) of developing MASLD. To evaluate the accuracy and clinical value of our prediction model, we employed receiver operating characteristic (ROC) curves and decision curve analysis (DCA) curves. Results Among the study population of 3424 participants (mean [SD] age, 54 [20] years, 1788 [52.22%] males) with hyperuricemia, 1670 participants had MASLD. Using Boruta's algorithm, SHAP and random forests, our analysis suggested that Triglyceride Glucose-Waist Circumference (TyG_WC) was one of the most significant variables in predicting MASLD risk, with an area under the receiver operating characteristic (AUROC) of 0.865. The restricted curve spline (RCS) revealed a positive association between the odds ratio of TyG_WC and MASLD, when compared with lowest quantile of TyG_WC, the risk of MASLD for highest quantile was 137.96 times higher. The predictive strategy incorporating TyG_WC notably enhanced the clinical model, with threshold probabilities spanning from approximately 0% to 100%, resulting in a significant improvement of the net benefit. Conclusions Our analysis found that TyG_WC was one of the most significant variables in predicting MASLD risk among individuals with hyperuricemia.https://doi.org/10.1186/s12876-025-03786-2Metabolic dysfunction-associated steatotic liver diseaseHyperuricemiaTriglyceride Glucose-Waist Circumference (TyG_WC) |
| spellingShingle | Qian-Qian Wang Ning Zhang Xiang Xu Si-Ang Lv Zhuo-Deng Huang Xi-Dai Long Jun Wu The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia BMC Gastroenterology Metabolic dysfunction-associated steatotic liver disease Hyperuricemia Triglyceride Glucose-Waist Circumference (TyG_WC) |
| title | The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia |
| title_full | The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia |
| title_fullStr | The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia |
| title_full_unstemmed | The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia |
| title_short | The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia |
| title_sort | role of triglyceride glucose waist circumference tyg wc in predicting metabolic dysfunction associated steatotic liver disease among individuals with hyperuricemia |
| topic | Metabolic dysfunction-associated steatotic liver disease Hyperuricemia Triglyceride Glucose-Waist Circumference (TyG_WC) |
| url | https://doi.org/10.1186/s12876-025-03786-2 |
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