Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis
In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent evidence suggests a role of dendritic cells (DC)...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/158956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850235354658897920 |
|---|---|
| author | Nathalie Deckx Inez Wens Amber H. Nuyts Wai-Ping Lee Niel Hens Gudrun Koppen Herman Goossens Pierre Van Damme Zwi N. Berneman Bert O. Eijnde Nathalie Cools |
| author_facet | Nathalie Deckx Inez Wens Amber H. Nuyts Wai-Ping Lee Niel Hens Gudrun Koppen Herman Goossens Pierre Van Damme Zwi N. Berneman Bert O. Eijnde Nathalie Cools |
| author_sort | Nathalie Deckx |
| collection | DOAJ |
| description | In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent evidence suggests a role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of one combined endurance/resistance exercise bout on the number and function of DC in MS patients and healthy controls. Our results show a rapid increase in the number of DC in response to physical exercise in both MS patients and controls. Further investigation revealed that in particular DC expressing the migratory molecules CCR5 and CD62L were increased upon acute physical activity. This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 following one exercise bout. Circulating DC display reduced TLR responsiveness after acute exercise, as evidenced by a less pronounced upregulation of activation markers, HLA-DR and CD86, on plasmacytoid DC and conventional DC, respectively. Our results indicate mobilization of DC, which may be less prone to drive inflammatory processes, following exercise. This may present a negative feedback mechanism for exercise-induced tissue damage and inflammation. |
| format | Article |
| id | doaj-art-10dd4fc80e894eec86711b10d6d433c5 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-10dd4fc80e894eec86711b10d6d433c52025-08-20T02:02:17ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/158956158956Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple SclerosisNathalie Deckx0Inez Wens1Amber H. Nuyts2Wai-Ping Lee3Niel Hens4Gudrun Koppen5Herman Goossens6Pierre Van Damme7Zwi N. Berneman8Bert O. Eijnde9Nathalie Cools10Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumREVAL Rehabilitation Research Centre, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, BelgiumLaboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumLaboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumInteruniversity Institute for Biostatistics and Statistical Bioinformatics (I-BIOSTAT), Hasselt University, 3590 Diepenbeek, BelgiumFlemish Institute of Technological Research (VITO), Unit Environmental Risk and Health, 2400 Mol, BelgiumLaboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumCentre for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumLaboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumREVAL Rehabilitation Research Centre, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, BelgiumLaboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, BelgiumIn healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. Since recent evidence suggests a role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of one combined endurance/resistance exercise bout on the number and function of DC in MS patients and healthy controls. Our results show a rapid increase in the number of DC in response to physical exercise in both MS patients and controls. Further investigation revealed that in particular DC expressing the migratory molecules CCR5 and CD62L were increased upon acute physical activity. This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 following one exercise bout. Circulating DC display reduced TLR responsiveness after acute exercise, as evidenced by a less pronounced upregulation of activation markers, HLA-DR and CD86, on plasmacytoid DC and conventional DC, respectively. Our results indicate mobilization of DC, which may be less prone to drive inflammatory processes, following exercise. This may present a negative feedback mechanism for exercise-induced tissue damage and inflammation.http://dx.doi.org/10.1155/2015/158956 |
| spellingShingle | Nathalie Deckx Inez Wens Amber H. Nuyts Wai-Ping Lee Niel Hens Gudrun Koppen Herman Goossens Pierre Van Damme Zwi N. Berneman Bert O. Eijnde Nathalie Cools Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis Mediators of Inflammation |
| title | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis |
| title_full | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis |
| title_fullStr | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis |
| title_full_unstemmed | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis |
| title_short | Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis |
| title_sort | rapid exercise induced mobilization of dendritic cells is potentially mediated by a flt3l and mmp 9 dependent process in multiple sclerosis |
| url | http://dx.doi.org/10.1155/2015/158956 |
| work_keys_str_mv | AT nathaliedeckx rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT inezwens rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT amberhnuyts rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT waipinglee rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT nielhens rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT gudrunkoppen rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT hermangoossens rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT pierrevandamme rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT zwinberneman rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT bertoeijnde rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis AT nathaliecools rapidexerciseinducedmobilizationofdendriticcellsispotentiallymediatedbyaflt3landmmp9dependentprocessinmultiplesclerosis |