The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signa...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/274564 |
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| author | Andrew J. Lilly William E. Johnson Christopher M. Bunce |
| author_facet | Andrew J. Lilly William E. Johnson Christopher M. Bunce |
| author_sort | Andrew J. Lilly |
| collection | DOAJ |
| description | The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses. It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations. However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions. In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche. |
| format | Article |
| id | doaj-art-10dc6583da354ac4bedd53a563684673 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-10dc6583da354ac4bedd53a5636846732025-02-03T01:27:37ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/274564274564The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell BehaviourAndrew J. Lilly0William E. Johnson1Christopher M. Bunce2School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UKSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UKSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UKThe concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses. It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations. However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions. In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche.http://dx.doi.org/10.4061/2011/274564 |
| spellingShingle | Andrew J. Lilly William E. Johnson Christopher M. Bunce The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour Stem Cells International |
| title | The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour |
| title_full | The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour |
| title_fullStr | The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour |
| title_full_unstemmed | The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour |
| title_short | The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour |
| title_sort | haematopoietic stem cell niche new insights into the mechanisms regulating haematopoietic stem cell behaviour |
| url | http://dx.doi.org/10.4061/2011/274564 |
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