An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections
Primary hepatic lymphomas (PHLs) are exceedingly rare. Many reported cases are associated with various viral serologies, and some viruses may be implicated in lymphomagenesis through emerging, though as-of-yet uncertain, mechanisms. A review of the literature reveals previously reported cases of PHL...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/5125086 |
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| author | Connor R. Zuraski Vinit Patil Katherine E. Schwetye |
| author_facet | Connor R. Zuraski Vinit Patil Katherine E. Schwetye |
| author_sort | Connor R. Zuraski |
| collection | DOAJ |
| description | Primary hepatic lymphomas (PHLs) are exceedingly rare. Many reported cases are associated with various viral serologies, and some viruses may be implicated in lymphomagenesis through emerging, though as-of-yet uncertain, mechanisms. A review of the literature reveals previously reported cases of PHL, some of which support the potential roles of the hepatitis B and C viruses (HBV and HCV) in the development of PHL. We describe an exceptional case of primary hepatic high-grade B-cell lymphoma, discovered at autopsy, in a patient whose clinical history is significant for coinfection with both HBV and HCV. Additionally, attempts at cytogenetic testing of formalin-fixed, paraffin-embedded (FFPE) autopsy tissues, which we performed approximately ten years after the original autopsy, led us to question the utility of older tissue blocks in molecular and some immunohistochemical assays. |
| format | Article |
| id | doaj-art-10d99531cdad4a7b84a0d9bccc3195ca |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-10d99531cdad4a7b84a0d9bccc3195ca2025-02-03T05:53:32ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/51250865125086An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV CoinfectionsConnor R. Zuraski0Vinit Patil1Katherine E. Schwetye2Department of Pathology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63110, USADepartment of Pathology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63110, USADepartment of Pathology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63110, USAPrimary hepatic lymphomas (PHLs) are exceedingly rare. Many reported cases are associated with various viral serologies, and some viruses may be implicated in lymphomagenesis through emerging, though as-of-yet uncertain, mechanisms. A review of the literature reveals previously reported cases of PHL, some of which support the potential roles of the hepatitis B and C viruses (HBV and HCV) in the development of PHL. We describe an exceptional case of primary hepatic high-grade B-cell lymphoma, discovered at autopsy, in a patient whose clinical history is significant for coinfection with both HBV and HCV. Additionally, attempts at cytogenetic testing of formalin-fixed, paraffin-embedded (FFPE) autopsy tissues, which we performed approximately ten years after the original autopsy, led us to question the utility of older tissue blocks in molecular and some immunohistochemical assays.http://dx.doi.org/10.1155/2019/5125086 |
| spellingShingle | Connor R. Zuraski Vinit Patil Katherine E. Schwetye An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections Case Reports in Pathology |
| title | An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections |
| title_full | An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections |
| title_fullStr | An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections |
| title_full_unstemmed | An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections |
| title_short | An Exceptional Case of Liver-Restricted High-Grade B-Cell Lymphoma in a Patient with Clinical History of HBV and HCV Coinfections |
| title_sort | exceptional case of liver restricted high grade b cell lymphoma in a patient with clinical history of hbv and hcv coinfections |
| url | http://dx.doi.org/10.1155/2019/5125086 |
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