Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities
Myocardial infarction (MI) continues to pose significant challenges in clinical treatment despite medical advancements. Natural products (NPs) derived from botanical and biological sources demonstrate considerable therapeutic potential through their ability to simultaneously address multiple patholo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002270 |
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| author | Mengmeng Li Siyi Wang Hanya Dong Min Wang Ye Sun Yu Bi Lixia Chen Anam Naseem Hai Jiang Hua Li Bingyou Yang Yan Liu |
| author_facet | Mengmeng Li Siyi Wang Hanya Dong Min Wang Ye Sun Yu Bi Lixia Chen Anam Naseem Hai Jiang Hua Li Bingyou Yang Yan Liu |
| author_sort | Mengmeng Li |
| collection | DOAJ |
| description | Myocardial infarction (MI) continues to pose significant challenges in clinical treatment despite medical advancements. Natural products (NPs) derived from botanical and biological sources demonstrate considerable therapeutic potential through their ability to simultaneously address multiple pathological features of MI. This comprehensive review examines the past decade of research investigating the therapeutic effects of various classes of NPs, notably terpenoids, flavonoids, alkaloids, phenolic acids, and phenylpropanoids in MI treatment. The analysis focuses on their multifaceted mechanisms of action, particularly their capacity to inhibit cellular apoptosis, reduce oxidative damage, attenuate fibrotic development, suppress inflammatory pathways, stimulate vascular regeneration, and normalize calcium homeostasis. Importantly, the discussion critically addresses the current limitations hindering clinical translation of NPs therapies, specifically focusing on bioavailability challenges and insufficient target specificity. Furthermore, this review also explores innovative solutions to these obstacles, particularly the significant importance of advanced drug delivery technologies and NPs for the future of personalized medicine and precision medicine. By systematically evaluating both the fundamental pharmacological properties and practical application barriers of NPs, this work provides valuable insights for future research directions in MI treatment. The synthesis of mechanistic understanding with translational considerations offers a framework for developing NPs-based therapies with improved clinical potential. |
| format | Article |
| id | doaj-art-10d09da2f00c4d2a97e522b634730e26 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-10d09da2f00c4d2a97e522b634730e262025-08-20T02:37:39ZengElsevierPharmacological Research1096-11862025-07-0121710780210.1016/j.phrs.2025.107802Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunitiesMengmeng Li0Siyi Wang1Hanya Dong2Min Wang3Ye Sun4Yu Bi5Lixia Chen6Anam Naseem7Hai Jiang8Hua Li9Bingyou Yang10Yan Liu11Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China; Corresponding authors.Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Corresponding author at: Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China; Corresponding authors.Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China; Corresponding authors.Myocardial infarction (MI) continues to pose significant challenges in clinical treatment despite medical advancements. Natural products (NPs) derived from botanical and biological sources demonstrate considerable therapeutic potential through their ability to simultaneously address multiple pathological features of MI. This comprehensive review examines the past decade of research investigating the therapeutic effects of various classes of NPs, notably terpenoids, flavonoids, alkaloids, phenolic acids, and phenylpropanoids in MI treatment. The analysis focuses on their multifaceted mechanisms of action, particularly their capacity to inhibit cellular apoptosis, reduce oxidative damage, attenuate fibrotic development, suppress inflammatory pathways, stimulate vascular regeneration, and normalize calcium homeostasis. Importantly, the discussion critically addresses the current limitations hindering clinical translation of NPs therapies, specifically focusing on bioavailability challenges and insufficient target specificity. Furthermore, this review also explores innovative solutions to these obstacles, particularly the significant importance of advanced drug delivery technologies and NPs for the future of personalized medicine and precision medicine. By systematically evaluating both the fundamental pharmacological properties and practical application barriers of NPs, this work provides valuable insights for future research directions in MI treatment. The synthesis of mechanistic understanding with translational considerations offers a framework for developing NPs-based therapies with improved clinical potential.http://www.sciencedirect.com/science/article/pii/S1043661825002270Natural productsMyocardial infarctionPathological mechanismTarget identificationDrug delivery system |
| spellingShingle | Mengmeng Li Siyi Wang Hanya Dong Min Wang Ye Sun Yu Bi Lixia Chen Anam Naseem Hai Jiang Hua Li Bingyou Yang Yan Liu Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities Pharmacological Research Natural products Myocardial infarction Pathological mechanism Target identification Drug delivery system |
| title | Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities |
| title_full | Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities |
| title_fullStr | Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities |
| title_full_unstemmed | Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities |
| title_short | Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities |
| title_sort | harnessing natural products for myocardial infarction therapy mechanistic insights and translational opportunities |
| topic | Natural products Myocardial infarction Pathological mechanism Target identification Drug delivery system |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002270 |
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