Epidrug screening identifies type I PRMT inhibitors as modulators of lysosomal exocytosis and drug sensitivity in cancers

Epidrug screening identifies type I PRMT inhibitors as modulators of lysosomal exocytosis and drug sensitivity in cancers

Abstract Epigenetic changes drive gene expression alterations, contributing to oncogenesis and drug resistance. Lysosomes play a key role in cell signaling and sequestering toxins, including chemotherapeutic agents, which are then expelled through lysosomal exocytosis—a process linked to drug resist...

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Bibliographic Details
Main Authors: Baris Sergi, Neslihan Yuksel-Catal, Selahattin Can Ozcan, Hamzah Syed, Umamaheswar Duvvuri, Kirill Kiselyov, Ceyda Acilan
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07900-w
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