Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics
The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Gruppo Italiano Frattura
2017-04-01
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| Series: | Fracture and Structural Integrity |
| Subjects: | |
| Online Access: | http://www.gruppofrattura.it/pdf/rivista/numero40/numero_40_art_8.pdf |
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| Summary: | The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). Body mass and relevant biochemical parameters were measured for the duration of the experimental protocol (37 weeks). Mechanical strength of both femurs of each animal was assessed in-vitro based on three point bending tests. It was re¬vealed that exposure to high-fat diet led to significant increase of body mass and cholesterol levels and also to substantial changes in bone mor-phology and strength. Ultimate stress for the animals exposed to high-fat diet and those exposed to high-fat-diet and exercise was 25% and 24% lower compared to control, respectively. Exercise increased bone thickness by 15% compared to animals that were not exposed to exer¬cise. It was concluded that high-fat-diet ap¬pears to have a detrimental effect on bone biomechanics and strength. Exer¬cise reversed the reduction in bone thickness that appears to be induced by high-fat diet. However no statistically significant increase in bone strength was observed. |
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| ISSN: | 1971-8993 1971-8993 |