Cytokine and Antimicrobial Peptide Levels in Cholelithiasis
Objective. To study the cytokines and antimicrobial peptides concentrations in patients with cholelitiasis during 1 year treatment before and after the surgery. Materials and methods. 38 patients with a cholelithiasis were examined and operated in the Educational-Surgical Clinic of the Azerbaijan...
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| Format: | Article |
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Liga-Inform ltd.
2021-03-01
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| Series: | Клінічна хірургія |
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| Online Access: | https://hirurgiya.com.ua/index.php/journal/article/view/897 |
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| author | K. F. Gasimova |
| author_facet | K. F. Gasimova |
| author_sort | K. F. Gasimova |
| collection | DOAJ |
| description | Objective. To study the cytokines and antimicrobial peptides concentrations in patients with cholelitiasis during 1 year treatment before and after the surgery.
Materials and methods. 38 patients with a cholelithiasis were examined and operated in the Educational-Surgical Clinic of the Azerbaijan Medical University. According to the treatment regimen after the operation the patients were divided into two groups: patients of the 1st group (n = 17) received standard treatment; patients of 2nd group (n = 21), in addition to standard treatment hepatoprotectors, combined enzyme preparations, pre- and probiotics were prescribed. The control group consisted of 14 apparently healthy individuals. The levels of inflammatory cytokines (interleukin-6 and tumor necrosis factor-α) in the blood and antimicrobial peptides (zonulin, calprotectin, and lactoferrin) in feces we studied with enzyme immunoassay method.
Results. In patients with cholelithiasis of the 1st group, the concentration of interleukin-6 was significantly increased by 5 times (p <0.001), the concentration of tumor necrosis factor-α - by 3.5 times (p <0.001), of zonulin - by 2.2 times (p = 0.012), of calprotectin - by 5.8 times (p <0.001, the concentration of lactoferrin - by 60 times (p <0.001), and in the 2nd group - by 4.8 times (p <0.001), by 3.1 times (p <0.001), on 91.7% (p = 0.011), by 5.8 times (p <0.001) and by 52.8 times (p <0.001) respectively in comparison with the control.
Conclusions. Standard postoperative treatment supplemented by hepatoprotectors, combined enzyme preparations, pre- and probiotics prescription leads to a positive dynamics of inflammatory mediators concentration and its normalization. |
| format | Article |
| id | doaj-art-10c8b2311b174aa092fe2b14413c151b |
| institution | Kabale University |
| issn | 0023-2130 2522-1396 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Liga-Inform ltd. |
| record_format | Article |
| series | Клінічна хірургія |
| spelling | doaj-art-10c8b2311b174aa092fe2b14413c151b2025-08-20T03:32:54ZengLiga-Inform ltd.Клінічна хірургія0023-21302522-13962021-03-01881-2232710.26779/2522-1396.2021.1-2.23897Cytokine and Antimicrobial Peptide Levels in CholelithiasisK. F. Gasimova0Azerbaijan Medical University, BakuObjective. To study the cytokines and antimicrobial peptides concentrations in patients with cholelitiasis during 1 year treatment before and after the surgery. Materials and methods. 38 patients with a cholelithiasis were examined and operated in the Educational-Surgical Clinic of the Azerbaijan Medical University. According to the treatment regimen after the operation the patients were divided into two groups: patients of the 1st group (n = 17) received standard treatment; patients of 2nd group (n = 21), in addition to standard treatment hepatoprotectors, combined enzyme preparations, pre- and probiotics were prescribed. The control group consisted of 14 apparently healthy individuals. The levels of inflammatory cytokines (interleukin-6 and tumor necrosis factor-α) in the blood and antimicrobial peptides (zonulin, calprotectin, and lactoferrin) in feces we studied with enzyme immunoassay method. Results. In patients with cholelithiasis of the 1st group, the concentration of interleukin-6 was significantly increased by 5 times (p <0.001), the concentration of tumor necrosis factor-α - by 3.5 times (p <0.001), of zonulin - by 2.2 times (p = 0.012), of calprotectin - by 5.8 times (p <0.001, the concentration of lactoferrin - by 60 times (p <0.001), and in the 2nd group - by 4.8 times (p <0.001), by 3.1 times (p <0.001), on 91.7% (p = 0.011), by 5.8 times (p <0.001) and by 52.8 times (p <0.001) respectively in comparison with the control. Conclusions. Standard postoperative treatment supplemented by hepatoprotectors, combined enzyme preparations, pre- and probiotics prescription leads to a positive dynamics of inflammatory mediators concentration and its normalization.https://hirurgiya.com.ua/index.php/journal/article/view/897cholelithiasis; interleukin-6; tumor necrosis factor-α; zonulin; calprotectin; lactoferrin. |
| spellingShingle | K. F. Gasimova Cytokine and Antimicrobial Peptide Levels in Cholelithiasis Клінічна хірургія cholelithiasis; interleukin-6; tumor necrosis factor-α; zonulin; calprotectin; lactoferrin. |
| title | Cytokine and Antimicrobial Peptide Levels in Cholelithiasis |
| title_full | Cytokine and Antimicrobial Peptide Levels in Cholelithiasis |
| title_fullStr | Cytokine and Antimicrobial Peptide Levels in Cholelithiasis |
| title_full_unstemmed | Cytokine and Antimicrobial Peptide Levels in Cholelithiasis |
| title_short | Cytokine and Antimicrobial Peptide Levels in Cholelithiasis |
| title_sort | cytokine and antimicrobial peptide levels in cholelithiasis |
| topic | cholelithiasis; interleukin-6; tumor necrosis factor-α; zonulin; calprotectin; lactoferrin. |
| url | https://hirurgiya.com.ua/index.php/journal/article/view/897 |
| work_keys_str_mv | AT kfgasimova cytokineandantimicrobialpeptidelevelsincholelithiasis |