Novel insights into mechanisms and therapeutics for presbycusis
Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and periph...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024172349 |
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| author | Xiaoying Lin Yiyuan Xu Chunmei Fan Guanbin Zhang |
| author_facet | Xiaoying Lin Yiyuan Xu Chunmei Fan Guanbin Zhang |
| author_sort | Xiaoying Lin |
| collection | DOAJ |
| description | Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and peripheral cochlear hair cells (HCs). Although hearing aids and cochlear implantations (CIs) are established approaches for alleviating symptoms of presbycusis, there are currently no preventive or curative measures available. This article provides a comprehensive discussion on the research progress pertaining to the classification, molecular mechanism, genetic susceptibility, as well as the applications and prospects of diverse therapeutic interventions of presbycusis. Building upon these discussions, promising interventions like gene therapy and stem cell (SC) therapy are proposed for their potential value in restoring cochlear function; thus aiming to pave new avenues for prevention and cure of presbycusis. |
| format | Article |
| id | doaj-art-10c69935d60544f3afbeaf43c75df983 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-10c69935d60544f3afbeaf43c75df9832025-01-17T04:50:30ZengElsevierHeliyon2405-84402025-01-01111e41203Novel insights into mechanisms and therapeutics for presbycusisXiaoying Lin0Yiyuan Xu1Chunmei Fan2Guanbin Zhang3Department of Research and Development, Fujian CapitalBio Medical Laboratory, Fuzhou, 350100, ChinaDepartment of Research and Development, Fujian CapitalBio Medical Laboratory, Fuzhou, 350100, ChinaClinical Lab and Medical Diagnostics Laboratory, Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, ChinaDepartment of Laboratory Medicine, Fujian Medical University, Fuzhou, 350122, China; Department of Laboratory Medicine, Mianyang People's Hospital, Mianyang, 621000, China; Corresponding author. Department of Laboratory Medicine, Fujian Medical University, Fuzhou 350122, China.Presbycusis, also referred to as age-related hearing loss, poses a substantial burden on both individuals and society. The hallmark of presbycusis is a progressive decrease in auditory sensitivity. Irreversible hearing loss occurs due to the limited regenerative capacity of spiral neurons and peripheral cochlear hair cells (HCs). Although hearing aids and cochlear implantations (CIs) are established approaches for alleviating symptoms of presbycusis, there are currently no preventive or curative measures available. This article provides a comprehensive discussion on the research progress pertaining to the classification, molecular mechanism, genetic susceptibility, as well as the applications and prospects of diverse therapeutic interventions of presbycusis. Building upon these discussions, promising interventions like gene therapy and stem cell (SC) therapy are proposed for their potential value in restoring cochlear function; thus aiming to pave new avenues for prevention and cure of presbycusis.http://www.sciencedirect.com/science/article/pii/S2405844024172349PresbycusisClassificationMechanismGenetic susceptibilityTherapeutics |
| spellingShingle | Xiaoying Lin Yiyuan Xu Chunmei Fan Guanbin Zhang Novel insights into mechanisms and therapeutics for presbycusis Heliyon Presbycusis Classification Mechanism Genetic susceptibility Therapeutics |
| title | Novel insights into mechanisms and therapeutics for presbycusis |
| title_full | Novel insights into mechanisms and therapeutics for presbycusis |
| title_fullStr | Novel insights into mechanisms and therapeutics for presbycusis |
| title_full_unstemmed | Novel insights into mechanisms and therapeutics for presbycusis |
| title_short | Novel insights into mechanisms and therapeutics for presbycusis |
| title_sort | novel insights into mechanisms and therapeutics for presbycusis |
| topic | Presbycusis Classification Mechanism Genetic susceptibility Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024172349 |
| work_keys_str_mv | AT xiaoyinglin novelinsightsintomechanismsandtherapeuticsforpresbycusis AT yiyuanxu novelinsightsintomechanismsandtherapeuticsforpresbycusis AT chunmeifan novelinsightsintomechanismsandtherapeuticsforpresbycusis AT guanbinzhang novelinsightsintomechanismsandtherapeuticsforpresbycusis |