Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes
Embryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardi...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422016000032 |
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| _version_ | 1850275056635084800 |
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| author | Jae Boum Youm |
| author_facet | Jae Boum Youm |
| author_sort | Jae Boum Youm |
| collection | DOAJ |
| description | Embryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardiac remodeling. ESC-CMs have many different aspects of morphology, electrophysiology, calcium handling, and bioenergetics compared with adult cardiomyocytes. They are immature in morphology, similar to sinus nodal-like in the electrophysiology, higher contribution of trans-sarcolemmal Ca2+ influx to Ca2+ handling, and higher dependence on anaerobic glycolysis. Here, I review a detailed electrophysiology and Ca2+ handling features of ESC-CMs during differentiation into adult cardiomyocytes to gain insights into how all the developmental changes are related to each other to display cardinal features of developing cardiomyocytes. |
| format | Article |
| id | doaj-art-10c659f85b1b48eb833545ba5df2e021 |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-10c659f85b1b48eb833545ba5df2e0212025-08-20T01:50:57ZengElsevierIntegrative Medicine Research2213-42202016-03-015131010.1016/j.imr.2015.12.007Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytesJae Boum YoumEmbryonic stem cell-derived cardiomyocytes (ESC-CMs) hold great interest in many fields of research including clinical applications such as stem cell and gene therapy for cardiac repair or regeneration. ESC-CMs are also used as a platform tool for pharmacological tests or for investigations of cardiac remodeling. ESC-CMs have many different aspects of morphology, electrophysiology, calcium handling, and bioenergetics compared with adult cardiomyocytes. They are immature in morphology, similar to sinus nodal-like in the electrophysiology, higher contribution of trans-sarcolemmal Ca2+ influx to Ca2+ handling, and higher dependence on anaerobic glycolysis. Here, I review a detailed electrophysiology and Ca2+ handling features of ESC-CMs during differentiation into adult cardiomyocytes to gain insights into how all the developmental changes are related to each other to display cardinal features of developing cardiomyocytes.http://www.sciencedirect.com/science/article/pii/S2213422016000032calcium handlingcardiomyocyteselectrophysiologyembryonic stem cellion channels |
| spellingShingle | Jae Boum Youm Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes Integrative Medicine Research calcium handling cardiomyocytes electrophysiology embryonic stem cell ion channels |
| title | Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes |
| title_full | Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes |
| title_fullStr | Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes |
| title_full_unstemmed | Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes |
| title_short | Electrophysiological properties and calcium handling of embryonic stem cell-derived cardiomyocytes |
| title_sort | electrophysiological properties and calcium handling of embryonic stem cell derived cardiomyocytes |
| topic | calcium handling cardiomyocytes electrophysiology embryonic stem cell ion channels |
| url | http://www.sciencedirect.com/science/article/pii/S2213422016000032 |
| work_keys_str_mv | AT jaeboumyoum electrophysiologicalpropertiesandcalciumhandlingofembryonicstemcellderivedcardiomyocytes |