General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD
Autoimmune thyroid disease (AITD) shows the highest incidence among organ-specific autoimmune diseases and is the most common thyroid disease in humans, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The susceptibility to autoimmune diseases is affected by increased autoantibody le...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3916395 |
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| author | Chen Xiaoheng Mei Yizhou He Bei Li Huilong Wang Xin Hu Rui Li Lu Ding Zhiguo |
| author_facet | Chen Xiaoheng Mei Yizhou He Bei Li Huilong Wang Xin Hu Rui Li Lu Ding Zhiguo |
| author_sort | Chen Xiaoheng |
| collection | DOAJ |
| description | Autoimmune thyroid disease (AITD) shows the highest incidence among organ-specific autoimmune diseases and is the most common thyroid disease in humans, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The susceptibility to autoimmune diseases is affected by increased autoantibody levels, susceptibility gene polymorphisms, environmental factors, and psychological factors, but the pathogenesis remains unclear. Various cytokines and related genes encoding them play important roles in the development and progression of AITD. CD152, an expression product of the CTLA-4 gene, downregulates T cell activation. The A/A genotype polymorphism in the CT60 locus may reduce the production of thyroid autoantibodies. The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT. GD is an organ-specific autoimmune disease involving increased secretion of thyroid hormone, whereas HT may be associated with the destruction of thyroid gland tissue and hypothyroidism. These two diseases exhibit similar pathogenesis but opposite trends in the clinical manifestations. In this review, we focus on the structure and function of these cytokines and related genes in AITD, as well as the association of polymorphisms with susceptibility to GD and HT, and attempt to describe their differences in pathogenesis and clinical manifestations. |
| format | Article |
| id | doaj-art-10c40802a06642fc9a60e4896a0849e7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-10c40802a06642fc9a60e4896a0849e72025-02-03T01:08:07ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/39163953916395General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITDChen Xiaoheng0Mei Yizhou1He Bei2Li Huilong3Wang Xin4Hu Rui5Li Lu6Ding Zhiguo7Department of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, ChinaDepartment of Medical Service, The Third Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of General Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaAutoimmune thyroid disease (AITD) shows the highest incidence among organ-specific autoimmune diseases and is the most common thyroid disease in humans, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The susceptibility to autoimmune diseases is affected by increased autoantibody levels, susceptibility gene polymorphisms, environmental factors, and psychological factors, but the pathogenesis remains unclear. Various cytokines and related genes encoding them play important roles in the development and progression of AITD. CD152, an expression product of the CTLA-4 gene, downregulates T cell activation. The A/A genotype polymorphism in the CT60 locus may reduce the production of thyroid autoantibodies. The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT. GD is an organ-specific autoimmune disease involving increased secretion of thyroid hormone, whereas HT may be associated with the destruction of thyroid gland tissue and hypothyroidism. These two diseases exhibit similar pathogenesis but opposite trends in the clinical manifestations. In this review, we focus on the structure and function of these cytokines and related genes in AITD, as well as the association of polymorphisms with susceptibility to GD and HT, and attempt to describe their differences in pathogenesis and clinical manifestations.http://dx.doi.org/10.1155/2017/3916395 |
| spellingShingle | Chen Xiaoheng Mei Yizhou He Bei Li Huilong Wang Xin Hu Rui Li Lu Ding Zhiguo General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD Mediators of Inflammation |
| title | General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD |
| title_full | General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD |
| title_fullStr | General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD |
| title_full_unstemmed | General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD |
| title_short | General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD |
| title_sort | general and specific genetic polymorphism of cytokines related gene in aitd |
| url | http://dx.doi.org/10.1155/2017/3916395 |
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