Mutant glycosidases for labeling sialoglycans with high specificity and affinity

Mutant glycosidases for labeling sialoglycans with high specificity and affinity

Abstract Affinity labeling of biomacromolecules is vital for bioimaging and functional studies. However, affinity probes recognizing glycans with high specificity remain scarce. Here we report the development of glycan recombinant affinity binders (GRABs) based on mutant bacterial sialidases, which...

Full description

Saved in:
Bibliographic Details
Main Authors: Shuyu Liang, Qi Tang, Xunzi Guo, Zi’an Li, Yilan Guo, Jinghan Chang, Bo Cheng, Qitao Song, Jiayu Sun, Peng Dai, Xing Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56629-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items