Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats

Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats

BackgroundExposures to environmental pollution and specific occupational hazards exacerbate pulmonary fibrosis which has a complex pathogenesis and lacks effective therapeutic drugs. The extract from Dracocephalum moldavica L. can alleviate pulmonary fibrosis through anti-inflammatory and anti-pyrop...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN
Format:	Article
Language:	English
Published:	Editorial Committee of Journal of Environmental and Occupational Medicine 2024-12-01
Series:	环境与职业医学
Subjects:	pulmonary fibrosis dracocephalum moldavica l. extract phosphoinositide 3-kinase/protein kinase b inflammatory network pharmacology animal experiment validation
Online Access:	http://www.jeom.org/article/cn/10.11836/JEOM24121
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hypolipidemic activity and mechanism of active components of Dracocephalum moldavica L. tea
by: Siqi Li, et al.
Published: (2025-05-01)

Dracocephalum moldavica L. tea alleviates high-fat diet-induced hyperlipidemia in rats via gut microbiota and lipid metabolism
by: Qinyu Li, et al.
Published: (2026-03-01)

Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease
by: Marjan Talebi, et al.
Published: (2025-02-01)

The Effect of Spraying Salicylic Acid and Beta-Aminobutyric Acid on Physiological and Biochemical Characteristics and Yield of Dracocephalum moldavica (L.)
by: Fatemeh Mahsa Karamoozian, et al.
Published: (2024-02-01)

Phenolic Combination and Comparison of Antioxidant Activity in Three Different Alcoholic Extracts of Dracocephalum moldavica L.
by: Behnaz Aslanipour, et al.
Published: (2017-03-01)

The effect of plant growth promoting rhizobacteria on germination and primary growth of Moldavian dragonhead (Dracocephalum moldavica L.)
by: V. Torfi, et al.
Published: (2017-10-01)

Active food packaging strategies: Promoting mutton quality using Lepidium sativum coatings and nanoemulsions of Dracocephalum moldavica essential oil
by: Mitra Ghodsi Sheykhjan, et al.
Published: (2025-06-01)

Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats
by: Shangjia Ma, et al.
Published: (2025-08-01)

Validation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway for Its Key Role in Wuzhuyu Decoction for Treating Chronic Atrophic Gastritis Based on Network Pharmacology and Metabolomics
by: Yong He, et al.
Published: (2025-01-01)

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis
by: Rajesh K Kasam, et al.
Published: (2020-08-01)

L-arginine mitigates cardiac lipid and glucose accumulation through leptin modulation and enhancement of PIK3 activities in high fat-fed male Wistar rats
by: Adewumi Oluwafemi Oyabambi, et al.
Published: (2024-12-01)

Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives
by: Marjan Talebi, et al.
Published: (2024-12-01)

Innovation in Breast Cancer Treatment and it’s Potential in Pakistan
by: Muhammad Moaz, et al.
Published: (2024-04-01)

Solanum trilobatum leaf extract-derived silver nanoparticles downregulate the PI3K/AKT/mTOR signaling pathway and attenuate oral squamous cell carcinoma cell proliferation
by: Anuradha Ganesan, et al.
Published: (2024-04-01)

An Elastase Inhibitor ShSPI from Centipede Attenuates Bleomycin-Induced Pulmonary Fibrosis
by: Xi Lian, et al.
Published: (2025-04-01)

In vitro evaluation of Dracocephalum lindbergii on growth and apoptosis induction against Leishmania major and cytokine analysis
by: Faham Khamesipour, et al.
Published: (2024-12-01)

Autophagy activation in breast cancer cells in vitro after the treatment with PI3K/AKT/mTOR inhibitors
by: D. D. Grigoreva, et al.
Published: (2022-12-01)

Ameliorative Mechanism of Malvidin-3-O-glucoside on Chlorpyrifos-Induced PC12 Cell Injury
by: ZHU Rongchen, JING Shiji, LI Qi, FU Chengguo, HE Yang, WEN Liankui
Published: (2025-07-01)

Dracocephalum kotschyi: Inhibition of critical enzyme relevant to type-2 diabetes, essential oil composition, bactericidal and anti-oxidant activity
by: Mehri Kazempour, et al.
Published: (2024-04-01)

Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT
by: Yajun Wang, et al.
Published: (2025-05-01)

Pirfenidone combined with UC-MSCs reversed bleomycin-induced pulmonary fibrosis
by: Jingran Xu, et al.
Published: (2025-08-01)

Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation
by: Jianhan He, et al.
Published: (2025-04-01)

Pulmonary cytotoxicity induced by bleomycin and methotrexate
by: Zh, V, Sheykh, et al.
Published: (2016-03-01)

Luteolin-Rich Fraction from Dracocephalum lindbergii: Promising Agent for Hypertension Treatment
by: Zahra Pezeshki, et al.
Published: (2025-05-01)

Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis
by: Jinhua Feng, et al.
Published: (2025-02-01)

Prevention of bleomycin-induced pulmonary fibrosis by vaccination with the Tocilizumab mimotope
by: Jin Guo, et al.
Published: (2024-12-01)

Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors
by: Xenia Lainscsek, et al.
Published: (2025-04-01)

Prevalence and spectrum of PIK3 mutations in breast cancer and their correlation with clinicopathological features: A cross-sectional observational study from South India
by: HS Darling, et al.
Published: (2025-01-01)

Comparison of Antioxidant Activity of Dracocephalum polychaetum Bornm and Nepeta cataria L. and Their Effect on Probiotic Bacteria in a Simulated Gastrointestinal Environment
by: Fatemeh Shahdadi, et al.
Published: (2021-03-01)

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis
by: Fenghua Zhang, et al.
Published: (2020-06-01)

Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis
by: Kangchen Li, et al.
Published: (2025-01-01)

Ameliorative effects of avocado oil on bleomycin‐induced lung fibrosis and oxidative stress in rats
by: Naoures Ochi, et al.
Published: (2025-02-01)

Self-assembled vectors derived from Aster tataricus L.f. mitigate bleomycin-induced pulmonary fibrosis in mice
by: Yuan Meng, et al.
Published: (2025-06-01)

PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
by: Bart Nieuwenhuis, et al.
Published: (2020-06-01)

Novel Insights Into Receptor Tyrosine Kinases in Pulmonary Arterial Hypertension
by: Wenze Wu, et al.
Published: (2025-08-01)

Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway
by: Ying-Wei Lan, et al.
Published: (2024-12-01)

Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor
by: Jiannong Dai, et al.
Published: (2024-12-01)

Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats
by: Xiaoyu Sun, et al.
Published: (2025-05-01)

Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion
by: Yue Jin, et al.
Published: (2025-07-01)

Phosphoinositide Signaling and Actin Polymerization Are Critical for Tip Growth in the Marine Red Alga <i>Pyropia yezoensis</i>
by: Ryunosuke Irie, et al.
Published: (2025-07-01)