The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer’s disease

The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer’s disease

Abstract The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, recognizing cytosolic damage-associated molecular patterns (DAMPs), and inducing the i...

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Bibliographic Details
Main Authors: Shuiyue Quan, Xiaofeng Fu, Huimin Cai, Ziye Ren, Yinghao Xu, Longfei Jia
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Neurodegeneration
Subjects:
MtDNA
cGAS
STING
Neuroinflammation
Alzheimer’s disease
Treatment
Online Access:https://doi.org/10.1186/s13024-025-00815-2
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