The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children
Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8–14 years participated in the stud...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7067292 |
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| author | Edith Cardenas-Vargas Jairo A. Nava Idalia Garza-Veloz Mayra C. Torres-Castañeda Carlos E. Galván-Tejada Miguel A. Cid-Baez Rosa E. Castañeda-Arteaga Yolanda Ortiz-Castro Perla M. Trejo-Ortiz Roxana Araujo-Espino Fabiana E. Mollinedo-Montaño Jose R. Muñoz-Torres Margarita L. Martinez-Fierro |
| author_facet | Edith Cardenas-Vargas Jairo A. Nava Idalia Garza-Veloz Mayra C. Torres-Castañeda Carlos E. Galván-Tejada Miguel A. Cid-Baez Rosa E. Castañeda-Arteaga Yolanda Ortiz-Castro Perla M. Trejo-Ortiz Roxana Araujo-Espino Fabiana E. Mollinedo-Montaño Jose R. Muñoz-Torres Margarita L. Martinez-Fierro |
| author_sort | Edith Cardenas-Vargas |
| collection | DOAJ |
| description | Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8–14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82 mg/dl and 11.0 μIU/ml in boys and 77.3 mg/dl and 12.3 μIU/ml in girls (P<0.05). Subjects with obesity at Tanner stages II–V showed increased FG levels (P<0.05). In boys with obesity, there was a decrease in HOMA-IR in Tanner stage IV and differences in age between boys with normal weight and those with obesity in Tanner V, being older the boys with obesity. Obesity in children and adolescents was associated with higher HOMA-IR values. In boys with obesity, IR increased at the end of pubertal maturation, with a delay in puberty. These findings should be considered on the establishment of IR cutoff values for pubertal population in Mexico and in the establishment of strategies to prevent the health problems related to obesity. |
| format | Article |
| id | doaj-art-10afc226f60d4c3b93370d6185514a67 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-10afc226f60d4c3b93370d6185514a672025-08-20T02:02:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/70672927067292The Influence of Obesity on Puberty and Insulin Resistance in Mexican ChildrenEdith Cardenas-Vargas0Jairo A. Nava1Idalia Garza-Veloz2Mayra C. Torres-Castañeda3Carlos E. Galván-Tejada4Miguel A. Cid-Baez5Rosa E. Castañeda-Arteaga6Yolanda Ortiz-Castro7Perla M. Trejo-Ortiz8Roxana Araujo-Espino9Fabiana E. Mollinedo-Montaño10Jose R. Muñoz-Torres11Margarita L. Martinez-Fierro12Hospital General Zacatecas “Luz González Cosío”, Servicios de Salud de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoServicio de Endocrinologia Pediatrica, Hospital General “Gaudencio González Garza, ” Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), 02990 Ciudad de Mexico, MexicoUnidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoHospital General Zacatecas “Luz González Cosío”, Servicios de Salud de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoUnidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoUnidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoUnidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoMolecular Medicine Laboratory, Unidad Academica de Medicina Humana y C.S., Universidad Autonoma de Zacatecas, Zacatecas, 98160 ZAC, MexicoObesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8–14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82 mg/dl and 11.0 μIU/ml in boys and 77.3 mg/dl and 12.3 μIU/ml in girls (P<0.05). Subjects with obesity at Tanner stages II–V showed increased FG levels (P<0.05). In boys with obesity, there was a decrease in HOMA-IR in Tanner stage IV and differences in age between boys with normal weight and those with obesity in Tanner V, being older the boys with obesity. Obesity in children and adolescents was associated with higher HOMA-IR values. In boys with obesity, IR increased at the end of pubertal maturation, with a delay in puberty. These findings should be considered on the establishment of IR cutoff values for pubertal population in Mexico and in the establishment of strategies to prevent the health problems related to obesity.http://dx.doi.org/10.1155/2018/7067292 |
| spellingShingle | Edith Cardenas-Vargas Jairo A. Nava Idalia Garza-Veloz Mayra C. Torres-Castañeda Carlos E. Galván-Tejada Miguel A. Cid-Baez Rosa E. Castañeda-Arteaga Yolanda Ortiz-Castro Perla M. Trejo-Ortiz Roxana Araujo-Espino Fabiana E. Mollinedo-Montaño Jose R. Muñoz-Torres Margarita L. Martinez-Fierro The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children International Journal of Endocrinology |
| title | The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children |
| title_full | The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children |
| title_fullStr | The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children |
| title_full_unstemmed | The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children |
| title_short | The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children |
| title_sort | influence of obesity on puberty and insulin resistance in mexican children |
| url | http://dx.doi.org/10.1155/2018/7067292 |
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