Oligosaccharide Lactate Nanoparticles Enhance Tissue Targeting: A Case Study of the Controlled Delivery of Bedaquiline to Cardiac Tissue in TB Pericarditis

Bedaquiline is known to shorten the duration of therapy of tuberculosis but has limitations, e.g., poor solubility and adverse effects such as prolongation of the QT interval. In this study, bedaquiline was incorporated into an inherently targeted nanosystem for improved permeation of the drug, with...

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Bibliographic Details
Main Authors: Simisola Ayodele, Pradeep Kumar, Armorel van Eyk, Pieter van der Bijl, Yahya E. Choonara
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/30/13/2845
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