Alternating 2D and 3D culture reduces cell size and extends the lifespan of placenta-derived mesenchymal stem cells

Alternating 2D and 3D culture reduces cell size and extends the lifespan of placenta-derived mesenchymal stem cells

BackgroundMesenchymal stem cells (MSCs) hold great promise for treating a variety of human diseases; however, their clinical translation is hindered by challenges in large‐scale expansion while preserving therapeutic potency and maintaining small cell size. Conventional 2D culture on rigid substrate...

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Bibliographic Details
Main Authors: Ying Pan, Li Han, Yakun Yang, Xinran Wu, Aijun Wang, Liangqi Xie, Wuqiang Zhu, Shue Wang, Yuguo Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stem cells
alternating 2D/3D culture
spheroid culture
cell size
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1632810/full
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