The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
Gestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is associated with a 50% increase in subsequent risk for type 2 diabetes. There is increasing interest in identifying biomarkers that may facilitate the stratification of subsequent type 2 diabetes risk among w...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-07-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1225 |
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| author | Oluwole Oluwafemi G. Arowolo Afolake Musa Ezekiel Levitt Naomi Matjila Mushi |
| author_facet | Oluwole Oluwafemi G. Arowolo Afolake Musa Ezekiel Levitt Naomi Matjila Mushi |
| author_sort | Oluwole Oluwafemi G. |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is associated with a 50% increase in subsequent risk for type 2 diabetes. There is increasing interest in identifying biomarkers that may facilitate the stratification of subsequent type 2 diabetes risk among women with GDM. In this study, we considered the choline acetyltransferase (ChAT) gene. CHAT plays a critical role in acetylcholine synthesis and regulates insulin secretion from the pancreatic islet to maintain glucose homeostasis. |
| format | Article |
| id | doaj-art-10ac1e20c2374ee2aa669f40a2e6cfbd |
| institution | Kabale University |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-10ac1e20c2374ee2aa669f40a2e6cfbd2025-08-20T03:28:19ZengDe GruyterOpen Medicine2391-54632025-07-01201566710.1515/med-2025-1225The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic associationOluwole Oluwafemi G.0Arowolo Afolake1Musa Ezekiel2Levitt Naomi3Matjila Mushi4Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, PMB 7700, Observatory, Cape Town, South AfricaBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Cape Town, South AfricaDepartment of Internal Medicine, Kaduna State University, Kaduna, NigeriaDepartment of Medicine, University of Cape Town, Cape Town, South AfricaDepartment of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South AfricaGestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is associated with a 50% increase in subsequent risk for type 2 diabetes. There is increasing interest in identifying biomarkers that may facilitate the stratification of subsequent type 2 diabetes risk among women with GDM. In this study, we considered the choline acetyltransferase (ChAT) gene. CHAT plays a critical role in acetylcholine synthesis and regulates insulin secretion from the pancreatic islet to maintain glucose homeostasis.https://doi.org/10.1515/med-2025-1225gestational diabetes mellitusplacentachatcholinegenotypevariants |
| spellingShingle | Oluwole Oluwafemi G. Arowolo Afolake Musa Ezekiel Levitt Naomi Matjila Mushi The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association Open Medicine gestational diabetes mellitus placenta chat choline genotype variants |
| title | The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association |
| title_full | The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association |
| title_fullStr | The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association |
| title_full_unstemmed | The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association |
| title_short | The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association |
| title_sort | identification of novel missense variant in chat gene in a patient with gestational diabetes denotes plausible genetic association |
| topic | gestational diabetes mellitus placenta chat choline genotype variants |
| url | https://doi.org/10.1515/med-2025-1225 |
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