Bladder Perforation Secondary to Primary Systemic Amyloidosis

Amyloidosis is a disorder of protein folding characterized by extracellular aggregation and deposition of amyloid protein fibrils. Light-chain amyloidosis, also known as primary systemic amyloidosis, is the most common form of the disease. We present a case of an 84-year-old male with a history of s...

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Main Authors: Christopher J. Dru, Tom S. Feng, Howard H. Kim
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Case Reports in Urology
Online Access:http://dx.doi.org/10.1155/2014/123795
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author Christopher J. Dru
Tom S. Feng
Howard H. Kim
author_facet Christopher J. Dru
Tom S. Feng
Howard H. Kim
author_sort Christopher J. Dru
collection DOAJ
description Amyloidosis is a disorder of protein folding characterized by extracellular aggregation and deposition of amyloid protein fibrils. Light-chain amyloidosis, also known as primary systemic amyloidosis, is the most common form of the disease. We present a case of an 84-year-old male with a history of systemic primary amyloidosis causing genitourinary, cardiac, and autonomic dysfunction who presented with hematuria and hypotension secondary to bladder perforation. He underwent open repair of a large extraperitoneal bladder defect. He ultimately died as a result of medical complications from his disease.
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spelling doaj-art-10aba382ad6c4e20a2c787b1c6e1345f2025-08-20T03:55:45ZengWileyCase Reports in Urology2090-696X2090-69782014-01-01201410.1155/2014/123795123795Bladder Perforation Secondary to Primary Systemic AmyloidosisChristopher J. Dru0Tom S. Feng1Howard H. Kim2Department of Urology, Cedars-Sinai Medical Group, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 870, Los Angeles, CA 90048, USADepartment of Urology, Cedars-Sinai Medical Group, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 870, Los Angeles, CA 90048, USADepartment of Urology, Cedars-Sinai Medical Group, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 870, Los Angeles, CA 90048, USAAmyloidosis is a disorder of protein folding characterized by extracellular aggregation and deposition of amyloid protein fibrils. Light-chain amyloidosis, also known as primary systemic amyloidosis, is the most common form of the disease. We present a case of an 84-year-old male with a history of systemic primary amyloidosis causing genitourinary, cardiac, and autonomic dysfunction who presented with hematuria and hypotension secondary to bladder perforation. He underwent open repair of a large extraperitoneal bladder defect. He ultimately died as a result of medical complications from his disease.http://dx.doi.org/10.1155/2014/123795
spellingShingle Christopher J. Dru
Tom S. Feng
Howard H. Kim
Bladder Perforation Secondary to Primary Systemic Amyloidosis
Case Reports in Urology
title Bladder Perforation Secondary to Primary Systemic Amyloidosis
title_full Bladder Perforation Secondary to Primary Systemic Amyloidosis
title_fullStr Bladder Perforation Secondary to Primary Systemic Amyloidosis
title_full_unstemmed Bladder Perforation Secondary to Primary Systemic Amyloidosis
title_short Bladder Perforation Secondary to Primary Systemic Amyloidosis
title_sort bladder perforation secondary to primary systemic amyloidosis
url http://dx.doi.org/10.1155/2014/123795
work_keys_str_mv AT christopherjdru bladderperforationsecondarytoprimarysystemicamyloidosis
AT tomsfeng bladderperforationsecondarytoprimarysystemicamyloidosis
AT howardhkim bladderperforationsecondarytoprimarysystemicamyloidosis