Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review
OBJECTIVE:. As survival following sepsis improves, there is increased attention on the health-related quality of life (HRQoL) of survivors following critical illness. The aim of this study is to systematically review the literature on the HRQoL of adult sepsis survivors following critical illness. D...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-04-01
|
| Series: | Critical Care Explorations |
| Online Access: | http://journals.lww.com/10.1097/CCE.0000000000001238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849311330869182464 |
|---|---|
| author | Sheraya De Silva, BSc(Hons) Anna Urwin, BPhysio Chantal Grimwood, BSc, BPT(Hons), GradCertHlthProfEd Ethan K.E. Goh, BMedSci, MD Alisa M. Higgins, PhD, MPH, BPhysio(Hons), GradDipBiostats Carol L. Hodgson, PhD, FACP, FAHMS |
| author_facet | Sheraya De Silva, BSc(Hons) Anna Urwin, BPhysio Chantal Grimwood, BSc, BPT(Hons), GradCertHlthProfEd Ethan K.E. Goh, BMedSci, MD Alisa M. Higgins, PhD, MPH, BPhysio(Hons), GradDipBiostats Carol L. Hodgson, PhD, FACP, FAHMS |
| author_sort | Sheraya De Silva, BSc(Hons) |
| collection | DOAJ |
| description | OBJECTIVE:. As survival following sepsis improves, there is increased attention on the health-related quality of life (HRQoL) of survivors following critical illness. The aim of this study is to systematically review the literature on the HRQoL of adult sepsis survivors following critical illness.
DATA SOURCES:. OVID MEDLINE, Embase, and CINAHL were searched using a combination of MeSH subject headings and keywords.
STUDY SELECTION:. English-language studies published between January 2009 and June 2024, which investigated the HRQoL of adult sepsis survivors at 90 days or more following critical illness.
DATA EXTRACTION:. Extracted data from included studies comprised HRQoL findings, the instruments administered, and representation of adult survivors following critical illness. Risk-of-bias quality assessment was assessed using the Cochrane Risk of Bias In Non-Randomised Studies – of Exposure tool. Selection of studies, data extraction, and quality assessment were conducted independently by two reviewers.
DATA SYNTHESIS:. Thrity-three eligible studies were yielded from 25,611 records, with the sample size among included studies ranging from 55 to 2,151 participants. Included studies were mostly conducted in Europe. The EuroQol 5-dimension three-level instrument was most commonly administered (19 [58%] studies). Our review found that adult sepsis survivors following critical illness have lower HRQoL than population norms, regardless of follow-up timepoint. No significant difference was found in the HRQoL of adult survivors following critical illness with or without sepsis. High risk of bias in included studies was mostly due to missing data and confounding.
CONCLUSIONS:. As survival following critical illness improves, future research on improving long-term HRQoL following sepsis is crucial. |
| format | Article |
| id | doaj-art-10a92317d0414df6a751e33e4a71d550 |
| institution | Kabale University |
| issn | 2639-8028 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Critical Care Explorations |
| spelling | doaj-art-10a92317d0414df6a751e33e4a71d5502025-08-20T03:53:27ZengWolters KluwerCritical Care Explorations2639-80282025-04-0174e123810.1097/CCE.0000000000001238202504000-00009Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic ReviewSheraya De Silva, BSc(Hons)0Anna Urwin, BPhysio1Chantal Grimwood, BSc, BPT(Hons), GradCertHlthProfEd2Ethan K.E. Goh, BMedSci, MD3Alisa M. Higgins, PhD, MPH, BPhysio(Hons), GradDipBiostats4Carol L. Hodgson, PhD, FACP, FAHMS51 Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.2 Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia.2 Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia.1 Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.1 Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.1 Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.OBJECTIVE:. As survival following sepsis improves, there is increased attention on the health-related quality of life (HRQoL) of survivors following critical illness. The aim of this study is to systematically review the literature on the HRQoL of adult sepsis survivors following critical illness. DATA SOURCES:. OVID MEDLINE, Embase, and CINAHL were searched using a combination of MeSH subject headings and keywords. STUDY SELECTION:. English-language studies published between January 2009 and June 2024, which investigated the HRQoL of adult sepsis survivors at 90 days or more following critical illness. DATA EXTRACTION:. Extracted data from included studies comprised HRQoL findings, the instruments administered, and representation of adult survivors following critical illness. Risk-of-bias quality assessment was assessed using the Cochrane Risk of Bias In Non-Randomised Studies – of Exposure tool. Selection of studies, data extraction, and quality assessment were conducted independently by two reviewers. DATA SYNTHESIS:. Thrity-three eligible studies were yielded from 25,611 records, with the sample size among included studies ranging from 55 to 2,151 participants. Included studies were mostly conducted in Europe. The EuroQol 5-dimension three-level instrument was most commonly administered (19 [58%] studies). Our review found that adult sepsis survivors following critical illness have lower HRQoL than population norms, regardless of follow-up timepoint. No significant difference was found in the HRQoL of adult survivors following critical illness with or without sepsis. High risk of bias in included studies was mostly due to missing data and confounding. CONCLUSIONS:. As survival following critical illness improves, future research on improving long-term HRQoL following sepsis is crucial.http://journals.lww.com/10.1097/CCE.0000000000001238 |
| spellingShingle | Sheraya De Silva, BSc(Hons) Anna Urwin, BPhysio Chantal Grimwood, BSc, BPT(Hons), GradCertHlthProfEd Ethan K.E. Goh, BMedSci, MD Alisa M. Higgins, PhD, MPH, BPhysio(Hons), GradDipBiostats Carol L. Hodgson, PhD, FACP, FAHMS Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review Critical Care Explorations |
| title | Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review |
| title_full | Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review |
| title_fullStr | Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review |
| title_full_unstemmed | Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review |
| title_short | Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review |
| title_sort | health related quality of life of adult sepsis survivors following critical illness a systematic review |
| url | http://journals.lww.com/10.1097/CCE.0000000000001238 |
| work_keys_str_mv | AT sherayadesilvabschons healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview AT annaurwinbphysio healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview AT chantalgrimwoodbscbpthonsgradcerthlthprofed healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview AT ethankegohbmedscimd healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview AT alisamhigginsphdmphbphysiohonsgraddipbiostats healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview AT carollhodgsonphdfacpfahms healthrelatedqualityoflifeofadultsepsissurvivorsfollowingcriticalillnessasystematicreview |