Fully automated MRI‐based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI‐Net

Fully automated MRI‐based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI‐Net

Abstract INTRODUCTION The locus coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). Magnetic resonance imaging–based LC features have shown potential to assess LC integrity in vivo. METHODS We present a deep learning–ba...

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Main Authors: Max Dünnwald, Friedrich Krohn, Alessandro Sciarra, Mousumi Sarkar, Anja Schneider, Klaus Fliessbach, Okka Kimmich, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Annika Spottke, Johanna Brustkern, Michael T. Heneka, Frederic Brosseron, Falk Lüsebrink, Dorothea Hämmerer, Emrah Düzel, Klaus Tönnies, Steffen Oeltze‐Jafra, Matthew J. Betts
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
biomarker
deep learning
locus coeruleus
magnetic resonance imaging
segmentation
Online Access:https://doi.org/10.1002/dad2.70118
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