O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carboplatin combination treatment

O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carboplatin combination treatment

Glioblastoma (GBM) is the most common and aggressive primary adult CNS tumor. Increased understanding of glioma biology is needed for novel treatment strategies and maximization of current therapies. The action of the widely used antiglioma drug, temozolomide (TMZ), relies on its ability to methylat...

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Bibliographic Details
Main Authors: Müge Sak, Brian J. Williams, Andrew J. Hey, Mayur Sharma, Leslie Schier, Megan J. Wilson, Mahatma Ortega, Alyssa I. Lara, Mikaela N. Brentlinger, Norman L. Lehman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Aurora A Kinase
AURKA
O6-methylguanine DNA methyltransferase
MGMT
GBM
anchorage-independent growth
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1552015/full
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