The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes
OBJECTIVE: Despite the availability of better biomarkers, basal day 3 follicle-stimulating hormone is widely available and often used as the first-line test in ovarian reserve evaluation. The aim of this study was to evaluate the outcomes of cycles with elevated (>12 IU/mL) basal follicle-stimul...
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| Format: | Article |
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Medical Network
2021-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/998 |
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| author | Inci Kahyaoglu Hatice Yilmaz Dogru Sezin Erturk Aksakal Iskender Kaplanoglu Serdar Dilbaz Leyla Mollamahmutoglu |
| author_facet | Inci Kahyaoglu Hatice Yilmaz Dogru Sezin Erturk Aksakal Iskender Kaplanoglu Serdar Dilbaz Leyla Mollamahmutoglu |
| author_sort | Inci Kahyaoglu |
| collection | DOAJ |
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OBJECTIVE: Despite the availability of better biomarkers, basal day 3 follicle-stimulating hormone is widely available and often used as the first-line test in ovarian reserve evaluation. The aim of this study was to evaluate the outcomes of cycles with elevated (>12 IU/mL) basal follicle-stimulating hormone values.
STUDY DESIGN: Cycles with basal day 3 follicle-stimulating hormone values >12 IU/mL were divided into four cohorts according to follicle-stimulating hormone levels: group I, follicle-stimulating hormone between 12-15 IU/m, group II between 15-20 IU/mL, group III between 20-25 IU/mL and group IV >25 IU/mL. Both demographic characteristics and controlled ovarian stimulation parameters were retrospectively reviewed.
RESULTS: Total antral follicle count was significantly higher in group I compared to the other three groups (p=0.001). Number of follicles ≥17 mm on human chorionic gonadotropin (hCG) day, number of retrieved oocytes, mature oocytes and fertilized oocytes were significantly higher in group I compared to the other groups (p=0.003, p=0.001, p=0.001, and p=0.001, respectively). No significant difference was found between groups regarding cancellation rates. The rate of embryo transfer per started cycle was significantly higher in group I compared to group III and group IV (p=0.001). Clinical pregnancy rates per embryo transfer were comparable among the groups.
CONCLUSION: Despite the retrieval of lower quantities of oocytes, reasonable pregnancy rates could be achieved if embryo transfer was performed in cycles with follicle-stimulating hormone values over 12 IU/mL.
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| format | Article |
| id | doaj-art-10a36342c6e048a5b40fdc83f2985b91 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-10a36342c6e048a5b40fdc83f2985b912025-02-11T21:12:59ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-08-0127210.21613/GORM.2019.998The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle OutcomesInci Kahyaoglu0Hatice Yilmaz Dogru1Sezin Erturk Aksakal2Iskender Kaplanoglu3Serdar Dilbaz4Leyla Mollamahmutoglu5Dr Zekai Tahir Burak Women’s Health Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, TurkeyGaziosmanpaşa University Faculty of Medicine, Department of Obstetrics and Gynecology, Tokat, TurkeyEtlik Zubeyde Hanım Women’s Health Research and Education Hospital, Department of Obstetrics and Gynecology Ankara, TurkeyEtlik Zubeyde Hanım Women’s Health Research and Education Hospital, Department of Obstetrics and Gynecology Ankara, TurkeyEtlik Zubeyde Hanım Women’s Health Research and Education Hospital, Department of Obstetrics and Gynecology Ankara, TurkeyDr Zekai Tahir Burak Women’s Health Research and Education Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey OBJECTIVE: Despite the availability of better biomarkers, basal day 3 follicle-stimulating hormone is widely available and often used as the first-line test in ovarian reserve evaluation. The aim of this study was to evaluate the outcomes of cycles with elevated (>12 IU/mL) basal follicle-stimulating hormone values. STUDY DESIGN: Cycles with basal day 3 follicle-stimulating hormone values >12 IU/mL were divided into four cohorts according to follicle-stimulating hormone levels: group I, follicle-stimulating hormone between 12-15 IU/m, group II between 15-20 IU/mL, group III between 20-25 IU/mL and group IV >25 IU/mL. Both demographic characteristics and controlled ovarian stimulation parameters were retrospectively reviewed. RESULTS: Total antral follicle count was significantly higher in group I compared to the other three groups (p=0.001). Number of follicles ≥17 mm on human chorionic gonadotropin (hCG) day, number of retrieved oocytes, mature oocytes and fertilized oocytes were significantly higher in group I compared to the other groups (p=0.003, p=0.001, p=0.001, and p=0.001, respectively). No significant difference was found between groups regarding cancellation rates. The rate of embryo transfer per started cycle was significantly higher in group I compared to group III and group IV (p=0.001). Clinical pregnancy rates per embryo transfer were comparable among the groups. CONCLUSION: Despite the retrieval of lower quantities of oocytes, reasonable pregnancy rates could be achieved if embryo transfer was performed in cycles with follicle-stimulating hormone values over 12 IU/mL. https://gorm.com.tr/index.php/GORM/article/view/998Assisted reproductive technologiesClinical pregnancyFollicle-stimulating hormonePoor ovarian response |
| spellingShingle | Inci Kahyaoglu Hatice Yilmaz Dogru Sezin Erturk Aksakal Iskender Kaplanoglu Serdar Dilbaz Leyla Mollamahmutoglu The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes Gynecology Obstetrics & Reproductive Medicine Assisted reproductive technologies Clinical pregnancy Follicle-stimulating hormone Poor ovarian response |
| title | The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes |
| title_full | The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes |
| title_fullStr | The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes |
| title_full_unstemmed | The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes |
| title_short | The Effect of Elevated Basal Follicle Stimulating Hormone Levels on Assisted Reproductive Technology Cycle Outcomes |
| title_sort | effect of elevated basal follicle stimulating hormone levels on assisted reproductive technology cycle outcomes |
| topic | Assisted reproductive technologies Clinical pregnancy Follicle-stimulating hormone Poor ovarian response |
| url | https://gorm.com.tr/index.php/GORM/article/view/998 |
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