A randomized study to compare the efficacy and safety of ketamine, levobupivacaine, and a combination of both as pre-incision surgical site infiltration for providing postoperative analgesia in patients undergoing elective abdominal hysterectomy under general anesthesia
Objectives: We aimed to compare the postoperative Visual Analog Scale (VAS) score, requirement of additional analgesia, side-effects, and patient satisfaction among elective hysterectomy patients using ketamine, levobupivacaine, and a combination of both. Materials and Methods: A comparative study...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-09-01
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| Series: | Annals of Medical Science and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/amsr.amsr_32_24 |
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| Summary: | Objectives:
We aimed to compare the postoperative Visual Analog Scale (VAS) score, requirement of additional analgesia, side-effects, and patient satisfaction among elective hysterectomy patients using ketamine, levobupivacaine, and a combination of both.
Materials and Methods:
A comparative study was conducted on 60 adult females, randomly divided into three groups of Group K: ketamine 1 mg/kg in saline, 20 mL, Group L: levobupivacaine 0.25%, 20 mL, and Group KL: ketamine 1 mg/kg in 0.25% levobupivacaine, 20 mL. The study drug was infiltrated 5 minutes before skin incision. The patient outcomes (hemodynamic parameters, pain, requirement of additional analgesia, and side-effects) were observed during the 24 h after surgery and compared. P < 0.05 was taken for reference in terms of significant results.
Results:
Group KL had the lowest pain VAS score at postoperative 1 h (P = 0.022), 2 h (P = <0.001), and 6 h (P = 0.001). The time of the first dose of pethidine requirement was longer and the cumulative pethidine requirement (24 h) was significantly less in group KL (P < 0.001). Nausea was present in six cases in group K, two cases of Group L, and none from group KL. The patient satisfaction score was significantly greater in group KL (3.30 ± 0.57) as compared to both groups K (1.90 ± 0.44) and L (2.50 ± 0.60), P = 0.0001.
Conclusion:
The combination of ketamine and levobupivacaine is a safe and efficacious alternative as pre-emptive analgesia among patients undergoing abdominal hysterectomies. The combination enhances relief from postoperative pain and provides much better patient satisfaction. |
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| ISSN: | 2949-785X 2949-7868 |