A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?

A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?

<h4>Background</h4>Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we pr...

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Main Authors: Podjanee Jittamala, Wuelton Monteiro, Menno R Smit, Belen Pedrique, Sabine Specht, Carlos J Chaccour, Céline Dard, Pascal Del Giudice, Virak Khieu, Annabel Maruani, Virgilio E Failoc-Rojas, Marimar Sáez-de-Ocariz, Antoni Soriano-Arandes, Jaime Piquero-Casals, Anne Faisant, Marie-Pierre Brenier-Pinchart, David Wimmersberger, Jean T Coulibaly, Jennifer Keiser, Franck Boralevi, Oliver Sokana, Michael Marks, Daniel Engelman, Lucia Romani, Andrew C Steer, Lorenz von Seidlein, Nicholas J White, Eli Harriss, Kasia Stepniewska, Georgina S Humphreys, Kalynn Kennon, Philippe J Guerin, Kevin C Kobylinski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009144&type=printable
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